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Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression

  • Authors:
    • Wei Wang
    • Yueping Sun
    • Xinxing Li
    • Hui Li
    • Yuying Chen
    • Ye Tian
    • Jing Yi
    • Jian Wang

  • View Affiliations

  • Published online on: July 14, 2011     https://doi.org/10.3892/or.2011.1390
  • Pages: 1143-1148
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Gallbladder carcinoma is known to be an aggressive malignancy and non-sensitive to routine chemotherapy; its prognosis is quite poor. In this study, we show that emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active com­ponent from Chinese medicinal herbs, can enhance apoptosis of gallbladder cancer cells induced by cisplatin (CDDP) in a reactive oxygen species (ROS)-dependent manner. The expression of survivin, which is involved in the inhibition of apoptosis, was measured after drug treatment and it was found that this could be suppressed by CDDP. Co-treatment with emodin additively inhibited survivin expression in a ROS-dependent manner. Further experiments proved that emodin potentiated the antitumor effects of CDDP in vivo by downregulating the expression of survivin without causing detectable toxic effects on normal tissues.

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November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Wang W, Sun Y, Li X, Li H, Chen Y, Tian Y, Yi J and Wang J: Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression. Oncol Rep 26: 1143-1148, 2011.
APA
Wang, W., Sun, Y., Li, X., Li, H., Chen, Y., Tian, Y. ... Wang, J. (2011). Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression. Oncology Reports, 26, 1143-1148. https://doi.org/10.3892/or.2011.1390
MLA
Wang, W., Sun, Y., Li, X., Li, H., Chen, Y., Tian, Y., Yi, J., Wang, J."Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression". Oncology Reports 26.5 (2011): 1143-1148.
Chicago
Wang, W., Sun, Y., Li, X., Li, H., Chen, Y., Tian, Y., Yi, J., Wang, J."Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression". Oncology Reports 26, no. 5 (2011): 1143-1148. https://doi.org/10.3892/or.2011.1390