Key genes and pathways in thyroid cancer based on gene set enrichment analysis

  • Authors:
    • Wenwu He
    • Bin Qi
    • Qiuxi Zhou
    • Chuansen Lu
    • Qi Huang
    • Lei Xian
    • Mingwu Chen
  • View Affiliations

  • Published online on: June 20, 2013     https://doi.org/10.3892/or.2013.2557
  • Pages: 1391-1397
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Abstract

The incidence of thyroid cancer and its associated morbidity has shown the most rapid increase among all cancers since 1982, but the mechanisms involved in thyroid cancer, particularly significant key genes induced in thyroid cancer, remain undefined. In many studies, gene probes have been used to search for key genes involved in causing and facilitating thyroid cancer. As a result, many possible virulence genes and pathways have been identified. However, these studies lack a case contrast for selecting the most possible virulence genes and pathways, as well as conclusive results with which to clarify the mechanisms of cancer development. In the present study, we used gene set enrichment and meta-analysis to select key genes and pathways. Based on gene set enrichment, we identified 5 downregulated and 4 upregulated mixed pathways in 6 tissue datasets. Based on the meta-analysis, there were 17 common pathways in the tissue datasets. One pathway, the p53 signaling pathway, which includes 13 genes, was identified by both the gene set enrichment analysis and meta-analysis. Genes are important elements that form key pathways. These pathways can induce the development of thyroid cancer later in life. The key pathways and genes identified in the present study can be used in the next stage of research, which will involve gene elimination and other methods of experimentation.

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September 2013
Volume 30 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
He W, Qi B, Zhou Q, Lu C, Huang Q, Xian L and Chen M: Key genes and pathways in thyroid cancer based on gene set enrichment analysis. Oncol Rep 30: 1391-1397, 2013.
APA
He, W., Qi, B., Zhou, Q., Lu, C., Huang, Q., Xian, L., & Chen, M. (2013). Key genes and pathways in thyroid cancer based on gene set enrichment analysis. Oncology Reports, 30, 1391-1397. https://doi.org/10.3892/or.2013.2557
MLA
He, W., Qi, B., Zhou, Q., Lu, C., Huang, Q., Xian, L., Chen, M."Key genes and pathways in thyroid cancer based on gene set enrichment analysis". Oncology Reports 30.3 (2013): 1391-1397.
Chicago
He, W., Qi, B., Zhou, Q., Lu, C., Huang, Q., Xian, L., Chen, M."Key genes and pathways in thyroid cancer based on gene set enrichment analysis". Oncology Reports 30, no. 3 (2013): 1391-1397. https://doi.org/10.3892/or.2013.2557