Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages

Gao,Bo; Wang,Yingmei; Qiu,Yan; Xia,Weiliang; Meng,Xianzhi; Lu,Ming; Zhang,Weihui; Qiao,Xin; Zhang,Yingmei; Xue,Dongbo

doi:10.3892/or.2014.3217

Bioinformatics screening regarding herbal components that targetedly regulate the function of tumour-associated macrophages

Authors:
- Bo Gao
- Yingmei Wang
- Yan Qiu
- Weiliang Xia
- Xianzhi Meng
- Ming Lu
- Weihui Zhang
- Xin Qiao
- Yingmei Zhang
- Dongbo Xue
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Affiliations: Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA, Central Laboratory, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
Published online on: May 23, 2014 https://doi.org/10.3892/or.2014.3217
Pages: 309-317

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Abstract

As an important component of tumour stroma, tumour-associated macrophages (TAMs) promote tumour development and progression. Herbs have been increasingly used in anticancer therapies due to their wide-ranging anticancer effects and minor side-effects. However, no herb-based treatments targeting TAMs have yet been proposed. To address this issue, screening using modular analysis bioinformatics techniques found 6 core functional modules for TAMs that contain 46 total genes. Moreover, 15 potential new anticancer drugs that regulate the genes in the 6 core modules were identified through bioinformatics techniques and Fisher's exact test. Our results provide a new research avenue for targeting TAMs in anticancer therapies.