Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-2024 Volume 51 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 51 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS

  • Authors:
    • Tomoyuki Nanamiya
    • Kiyoko Takane
    • Kiyoshi Yamaguchi
    • Yuya Okawara
    • Mariko Arakawa
    • Akari Saku
    • Tsuneo Ikenoue
    • Tomoko Fujiyuki
    • Misako Yoneda
    • Chieko Kai
    • Yoichi Furukawa
  • View Affiliations / Copyright

    Affiliations: Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108‑8639, Japan, Division of Virus Engineering, Institute of Industrial Science, The University of Tokyo, Tokyo 153‑8505, Japan, Division of Virological Medicine, Institute of Industrial Science, The University of Tokyo, Tokyo 153‑8505, Japan, Division of Infectious Disease Control Science, Institute of Industrial Science, The University of Tokyo, Tokyo 153‑8505, Japan
    Copyright: © Nanamiya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
    |
    Published online on: December 5, 2023
       https://doi.org/10.3892/or.2023.8676
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

PVRL4 (or nectin‑4) is a promising therapeutic target since its upregulated expression is found in a wide range of human cancer types. Enfortumab vedotin, an antibody‑drug conjugate targeting PVRL4, is clinically used for the treatment of urothelial bladder cancer. In addition, rMV‑SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through interaction with PVRL4. Although PVRL4 transcript levels are elevated in breast, lung and ovarian cancer, the mechanisms of its upregulation have not yet been uncovered. To clarify the regulatory mechanisms of elevated PVRL4 expression in breast cancer cells, Assay for Transposase‑Accessible Chromatin‑sequencing and chromatin immunoprecipitation‑sequencing (ChIP‑seq) data were used to search for its regulatory regions. Using breast cancer cells, an enhancer region was ultimately identified. Additional analyses, including ChIP and reporter assays, demonstrated that FOS interacted with the PVRL4 enhancer region, and that alterations of the FOS‑binding motifs in the enhancer region decreased reporter activity. Consistent with these data, exogenous expression of FOS enhanced the reporter activity and PVRL4 expression in breast cancer cells. Furthermore, RNA‑seq analysis using breast cancer cells treated with PVRL4 small interfering RNA revealed its possible involvement in the cytokine response and immune system. These data suggested that FOS was involved, at least partly, in the regulation of PVRL4 expression in breast cancer cells, and that elevated PVRL4 expression may regulate the response of cancer cells to cytokines and the immune system.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Narod SA, Iqbal J, Giannakeas V, Sopik V and Sun P: Breast cancer mortality after a diagnosis of ductal carcinoma in situ. JAMA Oncol. 1:888–896. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Chung CT and Carlson RW: Goals and objectives in the management of metastatic breast cancer. Oncologist. 8:514–520. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Duraivelan K and Samanta D: Emerging roles of the nectin family of cell adhesion molecules in tumour-associated pathways. Biochim Biophys Acta Rev Cancer. 1876:1885892021. View Article : Google Scholar : PubMed/NCBI

5 

Samanta D and Almo SC: Nectin family of cell-adhesion molecules: Structural and molecular aspects of function and specificity. Cell Mol Life Sci. 72:645–658. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Chatterjee S, Sinha S and Kundu CN: Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy. Eur J Pharmacol. 15:1745162021. View Article : Google Scholar : PubMed/NCBI

7 

Ooshio T, Fujita N, Yamada A, Sato T, Kitagawa Y, Okamoto R, Nakata S, Miki A, Irie K and Takai Y: Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J Cell Sci. 120:2352–2365. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Ishino R, Kawase Y, Kitawaki T, Sugimoto N, Oku M, Uchida S, Imataki O, Matsuoka A, Taoka T, Kawakami K, et al: Oncolytic virus therapy with HSV-1 for hematological malignancies. Mol Ther. 29:762–774. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, et al: Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature. 480:530–533. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Athanassiadou AM, Patsouris E, Tsipis A, Gonidi M and Athanassiadou P: The significance of survivin and nectin-4 expression in the prognosis of breast carcinoma. Folia Histochem Cytobiol. 49:26–33. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Fabre-Lafay S, Monville F, Garrido-Urbani S, Berruyer-Pouyet C, Ginestier C, Reymond N, Finetti P, Sauvan R, Adélaïde J, Geneix J, et al: Nectin-4 is a new histological and serological tumour associated marker for breast cancer. BMC Cancer. 7:732007. View Article : Google Scholar : PubMed/NCBI

12 

Takano A, Ishikawa N, Nishino R, Masuda K, Yasui W, Inai K, Nishimura H, Ito H, Nakayama H, Miyagi Y, et al: Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res. 69:6694–6703. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Derycke MS, Pambuccian SE, Gilks CB, Kalloger SE, Ghidouche A, Lopez M, Bliss RL, Geller MA, Argenta PA, Harrington KM and Skubitz AP: Nectin 4 overexpression in ovarian cancer tissues and serum: Potential role as a serum biomarker. Am J Clin Pathol. 134:835–845. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M and Elledge SJ: A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 30:e003582013. View Article : Google Scholar : PubMed/NCBI

15 

Siddharth S, Goutam K, Das S, Nayak A, Nayak D, Sethy C, Wyatt MD and Kundu CN: Nectin-4 is a breast cancer stem cell marker that induces WNT/β-catenin signaling via Pi3k/Akt axis. Int J Biochem Cell Biol. 89:85–94. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Deng H, Shi H, Chen L, Zhou Y and Jiang J: Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int. 19:1062019. View Article : Google Scholar : PubMed/NCBI

17 

Bellmunt J, Kim J, Reardon B, Perera-Bel J, Orsola A, Rodriguez-Vida A, Wankowicz SA, Bowden M, Barletta JA, Morote J, et al: Genomic predictors of good outcome, recurrence, or progression in high-grade T1 non-muscle-invasive bladder cancer. Cancer Res. 80:4476–4486. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Bouleftour W, Guillot A and Magne N: The anti-nectin 4: A promising tumor cells target. A systematic review. Mol Cancer Ther. 21:493–501. 2022. View Article : Google Scholar : PubMed/NCBI

19 

M-Rabet M, Cabaud O, Josselin E, Finetti P, Castellano R, Farina A, Agavnian-Couquiaud E, Saviane G, Collette Y, Viens P, et al: Nectin-4: A new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer. Ann Oncol. 28:769–776. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Sugiyama T, Yoneda M, Kuraishi T, Hattori S, Inoue Y, Sato H and Kai C: Measles virus selectively blind to signaling lymphocyte activation molecule as a novel oncolytic virus for breast cancer treatment. Gene Ther. 20:338–347. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Challita-Eid PM, Satpayev D, Yang P, An Z, Morrison K, Shostak Y, Raitano A, Nadell R, Liu W, Lortie DR, et al: Enfortumab vedotin antibody-drug conjugate targeting nectin-4 is a highly potent therapeutic agent in multiple preclinical cancer models. Cancer Res. 76:3003–3013. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Hagège H, Klous P, Braem C, Splinter E, Dekker J, Cathala G, de Laat W and Forné T: Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc. 2:1722–1733. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Schilit SLP and Morton CC: 3C-PCR: A novel proximity ligation-based approach to phase chromosomal rearrangement breakpoints with distal allelic variants. Hum Genet. 137:55–62. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, et al: Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer. PLoS One. 9:e857502014. View Article : Google Scholar : PubMed/NCBI

25 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

26 

Kharman-Biz A, Gao H, Ghiasvand R, Zhao C, Zendehdel K and Dahlman-Wright K: Expression of activator protein-1 (AP-1) family members in breast cancer. BMC Cancer. 13:4412013. View Article : Google Scholar : PubMed/NCBI

27 

Szalóki N, Krieger JW, Komáromi I, Tóth K and Vámosi G: Evidence for homodimerization of the c-Fos transcription factor in live cells revealed by fluorescence microscopy and computer modeling. Mol Cell Biol. 35:3785–3798. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Young DF, Andrejeva J, Li X, Inesta-Vaquera F, Dong C, Cowling VH, Goodbourn S and Randall RE: Human IFIT1 inhibits mRNA translation of rubulaviruses but not other members of the paramyxoviridae family. J Virol. 90:9446–9456. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Busse DC, Habgood-Coote D, Clare S, Brandt C, Bassano I, Kaforou M, Herberg J, Levin M, Eléouët JF, Kellam P and Tregoning JS: Interferon-induced protein 44 and interferon-induced protein 44-like restrict replication of respiratory syncytial virus. J Virol. 94:e00297–e00320. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Han Y, Bai X, Liu S, Zhu J, Zhang F, Xie L, Liu G, Jiang X, Zhang M, Huang Y, et al: XAF1 protects host against emerging RNA viruses by stabilizing IRF1-dependent antiviral immunity. J Virol. 96:e00774222022. View Article : Google Scholar : PubMed/NCBI

31 

Haller O and Kochs G: Mx genes: Host determinants controlling influenza virus infection and trans-species transmission. Hum Genet. 139:695–705. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, et al: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility. Sci Adv. 9:eadg52112023. View Article : Google Scholar : PubMed/NCBI

33 

Liao X, Xie H, Li S, Ye H, Li S, Ren K, Li Y, Xu M, Lin W, Duan X, et al: 2′, 5′-oligoadenylate synthetase 2 (OAS2) inhibits zika virus replication through activation of type I IFN signaling pathway. Viruses. 12:4182020. View Article : Google Scholar : PubMed/NCBI

34 

Duan R, Porter W and Safe S: Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: Role of estrogen receptor Sp1 complex formation. Endocrinology. 139:1981–1990. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Binato R, Corrêa S, Panis C, Ferreira G, Petrone I, da Costa IR and Abdelhay E: NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer. Sci Rep. 11:211592021. View Article : Google Scholar : PubMed/NCBI

36 

Kawahara T, Shareef HK, Aljarah AK, Ide H, Li Y, Kashiwagi E, Netto GJ, Zheng Y and Miyamoto H: ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression. Oncotarget. 6:29860–29876. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Zhou H, Zarubin T, Ji Z, Min Z, Zhu W, Downey JS, Lin S and Han J: Frequency and distribution of AP-1 sites in the human genome. DNA Res. 12:139–150. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Roskoski R Jr: ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol Res. 66:105–143. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Bakiri L, Reschke MO, Gefroh HA, Idarraga MH, Polzer K, Zenz R, Schett G and Wagner EF: Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 31:1506–1517. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Wang L, Yang M, Guo X, Yang Z, Liu S, Ji Y and Jin H: Estrogen-related receptor-α promotes gallbladder cancer development by enhancing the transcription of nectin-4. Cancer Sci. 111:1514–1527. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Reches A, Ophir Y, Stein N, Kol I, Isaacson B, Charpak Amikam Y, Elnekave A, Tsukerman P, Kucan Brlic P, Lenac T, et al: Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity. J Immunother Cancer. 8:e0002662020. View Article : Google Scholar : PubMed/NCBI

42 

Maruoka M, Kedashiro S, Ueda Y, Mizutani K and Takai Y: Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. J Biol Chem. 292:6895–6909. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Liau NPD, Laktyushin A, Lucet IS, Murphy JM, Yao S, Whitlock E, Callaghan K, Nicola NA, Kershaw NJ and Babon JJ: The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun. 9:15582018. View Article : Google Scholar : PubMed/NCBI

44 

Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES and Engreitz JM: Systematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 354:769–773. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nanamiya T, Takane K, Yamaguchi K, Okawara Y, Arakawa M, Saku A, Ikenoue T, Fujiyuki T, Yoneda M, Kai C, Kai C, et al: Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncol Rep 51: 17, 2024.
APA
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A. ... Furukawa, Y. (2024). Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncology Reports, 51, 17. https://doi.org/10.3892/or.2023.8676
MLA
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A., Ikenoue, T., Fujiyuki, T., Yoneda, M., Kai, C., Furukawa, Y."Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS". Oncology Reports 51.1 (2024): 17.
Chicago
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A., Ikenoue, T., Fujiyuki, T., Yoneda, M., Kai, C., Furukawa, Y."Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS". Oncology Reports 51, no. 1 (2024): 17. https://doi.org/10.3892/or.2023.8676
Copy and paste a formatted citation
x
Spandidos Publications style
Nanamiya T, Takane K, Yamaguchi K, Okawara Y, Arakawa M, Saku A, Ikenoue T, Fujiyuki T, Yoneda M, Kai C, Kai C, et al: Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncol Rep 51: 17, 2024.
APA
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A. ... Furukawa, Y. (2024). Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncology Reports, 51, 17. https://doi.org/10.3892/or.2023.8676
MLA
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A., Ikenoue, T., Fujiyuki, T., Yoneda, M., Kai, C., Furukawa, Y."Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS". Oncology Reports 51.1 (2024): 17.
Chicago
Nanamiya, T., Takane, K., Yamaguchi, K., Okawara, Y., Arakawa, M., Saku, A., Ikenoue, T., Fujiyuki, T., Yoneda, M., Kai, C., Furukawa, Y."Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS". Oncology Reports 51, no. 1 (2024): 17. https://doi.org/10.3892/or.2023.8676
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team