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Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review)

  • Authors:
    • Yuzhu Hou
    • Xiujun Zhao
    • Xiaoqian Nie
  • View Affiliations

  • Published online on: January 26, 2024     https://doi.org/10.3892/or.2024.8709
  • Article Number: 50
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer is a prevalent gynecological malignancy associated with a high mortality rate and a low 5‑year survival rate. Typically, >70% of patients present with an advanced stage of the disease, resulting in a high number of ovarian cancer‑associated deaths worldwide. Over the past decade, adoptive cellular immunotherapy has been investigated in clinical trials, and the results have led to the increased use in cancer treatment. Natural killer (NK) cells are cytotoxic lymphoid cells that recognize and lyse transformed cells, thereby impeding tumor growth. Thus, NK cells exhibit potential as a form of immunotherapy in the treatment of cancer. However, some patients with ovarian cancer treated with NK cells have experienced unsatisfactory outcomes. Therefore, further optimization of NK cells is required to increase the number of patients achieving long‑term remission. In the present review article, studies focusing on improving NK cell function were systematically summarized, and innovative strategies that augment the anticancer properties of NK cells were proposed.
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March-2024
Volume 51 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Hou Y, Zhao X and Nie X: Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review). Oncol Rep 51: 50, 2024.
APA
Hou, Y., Zhao, X., & Nie, X. (2024). Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review). Oncology Reports, 51, 50. https://doi.org/10.3892/or.2024.8709
MLA
Hou, Y., Zhao, X., Nie, X."Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review)". Oncology Reports 51.3 (2024): 50.
Chicago
Hou, Y., Zhao, X., Nie, X."Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review)". Oncology Reports 51, no. 3 (2024): 50. https://doi.org/10.3892/or.2024.8709