Open Access

Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review)

  • Authors:
    • Peiting Wu
    • Jianlin Chen
    • Hui Li
    • Haiyuan Lu
    • Yukun Li
    • Juan Zhang
  • View Affiliations

  • Published online on: December 5, 2024     https://doi.org/10.3892/or.2024.8851
  • Article Number: 18
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ferroptosis is a form of programmed cell death that is distinct from apoptosis. The mechanism involves redox‑active metallic iron and is characterized by an abnormal increase in iron‑dependent lipid reactive oxygen species, which results in high levels of membrane lipid peroxides. The relationship between ferroptosis and gynaecological tumours is complex. Ferroptosis can regulate tumour proliferation, metastasis and chemotherapy resistance, and targeting ferroptosis is a promising antitumour approach. Ferroptosis interacts with mechanisms related to tumorigenesis and development, such as macrophage polarization, the neutrophil trap network, mitochondrial autophagy and cuproptosis. The present review examines recent information on the interaction between the molecular mechanism of ferroptosis and other tumour‑related mechanisms, as well as the involvement of ferroptosis in gynaecological tumours, to identify implications for gynaecological cancer therapy.
View Figures
View References

Related Articles

Journal Cover

February-2025
Volume 53 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wu P, Chen J, Li H, Lu H, Li Y and Zhang J: Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review). Oncol Rep 53: 18, 2025.
APA
Wu, P., Chen, J., Li, H., Lu, H., Li, Y., & Zhang, J. (2025). Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review). Oncology Reports, 53, 18. https://doi.org/10.3892/or.2024.8851
MLA
Wu, P., Chen, J., Li, H., Lu, H., Li, Y., Zhang, J."Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review)". Oncology Reports 53.2 (2025): 18.
Chicago
Wu, P., Chen, J., Li, H., Lu, H., Li, Y., Zhang, J."Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review)". Oncology Reports 53, no. 2 (2025): 18. https://doi.org/10.3892/or.2024.8851