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Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors

  • Authors:
    • M Kitamura
    • K Arai
    • Y Iwasaki
    • M Toi

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  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.151
  • Pages: 151-153
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

TNP-470 is known to inhibit angiogenesis. In this study, we investigated the antitumor effect of TNP-470 in colon 26 tumors. A dose dependent growth inhibition of tumor and liver metastasis was observed. An additive administration of PSK enhanced inhibitory effect of the tumor. Combined treatment of TNP-470 and 5-FU significantly prolonged the life span compared to the TNP-470 and 5-FU group. It is suggested that the combination of TNP-470 and 5-FU might be effective for the treatment of colon cancer and PSK might increase the antitumor effect from the viewpoint of immunity and angiogenetic mechanism.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Kitamura M, Arai K, Iwasaki Y and Toi M: Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors. Oncol Rep 3: 151-153, 1996.
APA
Kitamura, M., Arai, K., Iwasaki, Y., & Toi, M. (1996). Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors. Oncology Reports, 3, 151-153. https://doi.org/10.3892/or.3.1.151
MLA
Kitamura, M., Arai, K., Iwasaki, Y., Toi, M."Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors". Oncology Reports 3.1 (1996): 151-153.
Chicago
Kitamura, M., Arai, K., Iwasaki, Y., Toi, M."Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors". Oncology Reports 3, no. 1 (1996): 151-153. https://doi.org/10.3892/or.3.1.151