Ras inhibitors
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- Published online on: January 1, 1996 https://doi.org/10.3892/or.3.1.7
- Pages: 7-14
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Abstract
A number of proteins and low-molecular weight compounds have been reported to suppress the activity toward ras-oncogenes and their products. These include anti-lias antibody, inhibitors of Ras activation, Ras dominant negative mutants, inhibitors of processing of newly-synthesized Ras, suppressors and inhibitors of downstream effecters and genetic probes such as anti-sense oligonucleotides and ribozymes. There are also other Ras inhibitors whose action mechanisms remain to be proved. Some of these inhibitors might be useful as cancer therapeutic agents.