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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 1996 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1996 Volume 3 Issue 3

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Article

Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines

  • Authors:
    • H Yam
    • S Wu
    • L Yang
    • S ChengChew
    • J Zheng
    • B Wu
    • E Chew

  • View Affiliations / Copyright

    Affiliations: CHINESE UNIV HONG KONG,DEPT ANAT,SHA TIN,HONG KONG. CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG. BEIJING MED UNIV,DEPT PATHOL,BEIJING,PEOPLES R CHINA. NORMAN BETHUNE UNIV,DEPT PATHOL,JILIN,PEOPLES R CHINA.
  • Pages: 469-472
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/or.3.3.469
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Abstract

Interactions between tumor cells and laminin play an important role in the complex cascade of events in metastasis. We investigated the association of laminin receptor DNA fragments with nuclear matrix in two carcinoma cell lines with different metastatic potentials. Two fragments of DNA (474 bp and 855 bp) were amplified and detected in the genomic DNA of both cell lines. With the extraction of residual DNA from nuclear matrix, positive association of the 474 bp DNA fragment with nuclear matrix was demonstrated in both cell lines. Nevertheless, the intensity of this amplified product in the high metastatic cell line is much stronger than that in the low metastatic cell line. The long DNA fragment was not detected in both cell lines indicating that part of the laminin receptor gene was hardly intact after sequential extraction with detergent, high salt and enzymes. Our findings show the possibility that the attachment of the 474 bp DNA fragment to nuclear matrix may contribute to the difference in metastatic properties of these two cell lines.

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Copy and paste a formatted citation
Spandidos Publications style
Yam H, Wu S, Yang L, ChengChew S, Zheng J, Wu B and Chew E: Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines. Oncol Rep 3: 469-472, 1996.
APA
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., & Chew, E. (1996). Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines. Oncology Reports, 3, 469-472. https://doi.org/10.3892/or.3.3.469
MLA
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., Chew, E."Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines". Oncology Reports 3.3 (1996): 469-472.
Chicago
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., Chew, E."Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines". Oncology Reports 3, no. 3 (1996): 469-472. https://doi.org/10.3892/or.3.3.469
Copy and paste a formatted citation
x
Spandidos Publications style
Yam H, Wu S, Yang L, ChengChew S, Zheng J, Wu B and Chew E: Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines. Oncol Rep 3: 469-472, 1996.
APA
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., & Chew, E. (1996). Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines. Oncology Reports, 3, 469-472. https://doi.org/10.3892/or.3.3.469
MLA
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., Chew, E."Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines". Oncology Reports 3.3 (1996): 469-472.
Chicago
Yam, H., Wu, S., Yang, L., ChengChew, S., Zheng, J., Wu, B., Chew, E."Association of laminin receptor gene fragments with nuclear matrices in high and low metastatic cancer cell lines". Oncology Reports 3, no. 3 (1996): 469-472. https://doi.org/10.3892/or.3.3.469
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