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Spermidine/spermine N-1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat

  • Authors:
    • H Takami
    • S Kodaira

  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/or.3.3.575
  • Pages: 575-577
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We investigated whether spermidine/spermine N-1-acetyltransferase (SSAT) might be a useful marker of 1,2-dimethylhydrazine (DMH)-induced colorectal tumors in rats. Male Wistar rats were given DMH weekly for 5 weeks (150 mg/kg/dose), and then sacrificed 5, 10, 15 or 20 weeks after the first dose. Tumors were detected in 2 of 6 rats sacrificed at 10 weeks. Colorectal mucosal SSAT activity was 25.8+/-2.4 pmoles/mg/min before dosing, and only slightly higher at 5 weeks (36.8+/-10.0). From week 5 onward, activity rose sharply and significantly, reaching 87.2+/-29.0 by week 20. These results indicate that SSAT is an excellent marker of DMH-induced colonic carcinogenesis.

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May 1996
Volume 3 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Takami H and Kodaira S: Spermidine/spermine N-1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat. Oncol Rep 3: 575-577, 1996.
APA
Takami, H., & Kodaira, S. (1996). Spermidine/spermine N-1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat. Oncology Reports, 3, 575-577. https://doi.org/10.3892/or.3.3.575
MLA
Takami, H., Kodaira, S."Spermidine/spermine N-1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat". Oncology Reports 3.3 (1996): 575-577.
Chicago
Takami, H., Kodaira, S."Spermidine/spermine N-1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat". Oncology Reports 3, no. 3 (1996): 575-577. https://doi.org/10.3892/or.3.3.575