Expression of GalCer sulfotransferase by human uterine endometrial carcinoma cell lines
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- Published online on: July 1, 1996 https://doi.org/10.3892/or.3.4.657
- Pages: 657-660
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Abstract
We investigated the expression of sulfoglycolipids in several gynecological cancer cell lines by metabolic labeling with S-35-sulfate as well as the activity of GalCer sulfotransferase (ST) and arylsulfatase A (ASA), enzymes which are responsible for the synthesis and degradation of sulfoglycolipids. The endometrial carcinoma cell lines expressed sulfoglycolipids and showed ST activity, indicating that increased synthesis of sulfoglycolipids due to elevated ST activity is a characteristic of endometrial carcinoma that distinguishes it from other carcinomas. These cell lines could provide a useful model for studying the functions of sulfoglycolipids as well as biological properties of ST in cancer cells.
