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Vascular endothelial growth factor-121 mRNA expression and neomicrovessel density in primary lung cancer

  • Authors:
    • Y Ohta
    • Y Watanabe
    • M Oda
    • Y Hayashi
    • Y Endo
    • T Sasaki

  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/or.3.4.713
  • Pages: 713-717
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The correlation between vascular endothelial growth factor (VEGF)121 mRNA expression and microvessel density was examined in 42 cases of primary lung cancer. Microvessels in tumors were highlighted by staining endothelial cells for factor VIII, CD31, and BNH9. The microvessel density in a high VEGF121 expressing group was significantly greater than that in the low expressing group in the assessment with anti-CD31 antibody. The difference of survival stratified by the vessel density was significant in patients. with stage I disease. The results suggest a relationship between neomicrovessel density and VEGF121. VEGF121 may be a useful marker of the tumor neovascularization in lung cancer.

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July 1996
Volume 3 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Ohta Y, Watanabe Y, Oda M, Hayashi Y, Endo Y and Sasaki T: Vascular endothelial growth factor-121 mRNA expression and neomicrovessel density in primary lung cancer. Oncol Rep 3: 713-717, 1996.
APA
Ohta, Y., Watanabe, Y., Oda, M., Hayashi, Y., Endo, Y., & Sasaki, T. (1996). Vascular endothelial growth factor-121 mRNA expression and neomicrovessel density in primary lung cancer. Oncology Reports, 3, 713-717. https://doi.org/10.3892/or.3.4.713
MLA
Ohta, Y., Watanabe, Y., Oda, M., Hayashi, Y., Endo, Y., Sasaki, T."Vascular endothelial growth factor-121 mRNA expression and neomicrovessel density in primary lung cancer". Oncology Reports 3.4 (1996): 713-717.
Chicago
Ohta, Y., Watanabe, Y., Oda, M., Hayashi, Y., Endo, Y., Sasaki, T."Vascular endothelial growth factor-121 mRNA expression and neomicrovessel density in primary lung cancer". Oncology Reports 3, no. 4 (1996): 713-717. https://doi.org/10.3892/or.3.4.713