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Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice

  • Authors:
    • K Aizawa
    • T Motoyama
    • K Ueki
    • S Suzuki
    • N Tanaka
    • H Yabusaki
    • T Suzuki
    • K Hatakeyama

  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.397
  • Pages: 397-400
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Abstract

We have examined the effects of chemotherapeutic drugs on tumor growth and metastasis of human alpha-fetoprotein-producing gastric carcinoma (AFPGC) xenografts growing in nude mice. These xenografts consisted of 3 hepatoid adenocarcinomas and 2 non-hepatoid, poorly differentiated adenocarcinomas. Mitomycin C and cisplatin inhibited the tumor growth and liver metastasis of hepatoid adenocarcinomas in nude mice. 5-fluorouracil also inhibited the growth of hepatoid adenocarcinomas but did not exhibit a significant antimetastatic action. Doxorubicin was effective only against non-hepatoid adenocarcinomas. These results indicate that chemotherapeutic drugs for AFPGC should be used according to the subtype of the tumor.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Aizawa K, Motoyama T, Ueki K, Suzuki S, Tanaka N, Yabusaki H, Suzuki T and Hatakeyama K: Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice. Oncol Rep 4: 397-400, 1997.
APA
Aizawa, K., Motoyama, T., Ueki, K., Suzuki, S., Tanaka, N., Yabusaki, H. ... Hatakeyama, K. (1997). Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice. Oncology Reports, 4, 397-400. https://doi.org/10.3892/or.4.2.397
MLA
Aizawa, K., Motoyama, T., Ueki, K., Suzuki, S., Tanaka, N., Yabusaki, H., Suzuki, T., Hatakeyama, K."Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice". Oncology Reports 4.2 (1997): 397-400.
Chicago
Aizawa, K., Motoyama, T., Ueki, K., Suzuki, S., Tanaka, N., Yabusaki, H., Suzuki, T., Hatakeyama, K."Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice". Oncology Reports 4, no. 2 (1997): 397-400. https://doi.org/10.3892/or.4.2.397