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Changes in c-src activity in a human colon cancer cell line during differentiation

  • Authors:
    • V Sovova
    • D Kucerova
    • M Liskova
    • E Sloncova
    • Z Tuhackova

  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.451
  • Pages: 451-453
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Abstract

Sodium butyrate is a potent agent inducing transient differentiation of colorectal carcinoma cell line HT29. Besides an increase in the level of alkaline phosphatase and morphological changes, this differentiation is followed by a great reduction of kinase activity of the c-src gene product (pp60(c-src)), combined with a sharp decrease in binding of pp60(c-src) to GST-src SH2+SH3 fusion proteins. This finding suggests that the cause of the reduction of pp60(c-src) kinase activity could be an inactive conformation of the pp60(c-src) molecule in sodium butyrate-treated HT29 cells.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Sovova V, Kucerova D, Liskova M, Sloncova E and Tuhackova Z: Changes in c-src activity in a human colon cancer cell line during differentiation. Oncol Rep 4: 451-453, 1997.
APA
Sovova, V., Kucerova, D., Liskova, M., Sloncova, E., & Tuhackova, Z. (1997). Changes in c-src activity in a human colon cancer cell line during differentiation. Oncology Reports, 4, 451-453. https://doi.org/10.3892/or.4.2.451
MLA
Sovova, V., Kucerova, D., Liskova, M., Sloncova, E., Tuhackova, Z."Changes in c-src activity in a human colon cancer cell line during differentiation". Oncology Reports 4.2 (1997): 451-453.
Chicago
Sovova, V., Kucerova, D., Liskova, M., Sloncova, E., Tuhackova, Z."Changes in c-src activity in a human colon cancer cell line during differentiation". Oncology Reports 4, no. 2 (1997): 451-453. https://doi.org/10.3892/or.4.2.451