V-onc product expression in early phase post perinatal retrovirus infection predictive of malignancy of induced lesions
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- Published online on: May 1, 1997 https://doi.org/10.3892/or.4.3.535
- Pages: 535-537
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Abstract
Sixteen sarcomas developed in rats within 40 days post perinatal infection with feline sarcoma virus of Snyder-Theilen strain were examined to elucidate the association of the viral oncogene product (P85) expression with malignancy of developed sarcomas. Of these, 6 grew up to index-finger-tip-size, consisted of spindle shaped sarcoma cells and had no metastasis (group A), and 10 grew over thumb-tip-size, consisted of polygonal shaped sarcoma cells and had frequent metastasis (group B). One group A tumor and 8 group B tumors expressed P85. The v-onc product expression was thus found to be predictive of malignancy of induced tumors.