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Enhancement of sensitivity to CDDP in human pharyngeal carcinoma cells by H-7, a protein kinase inhibitor

  • Authors:
    • I Noda
    • H Saito
    • N Tanaka
    • C Sugimoto
    • S Fujieda

  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.579
  • Pages: 579-582
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We investigated the synergetic effects of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) on cis-diamminedichloroplatinum(II) (CDDP) cytotoxicity to KB cells, a human pharyngeal carcinoma cell line, and explored the possible mechanism whereby it exerted these effects. In vitro treatment with H-7 markedly decreased protein kinase C (PKC) activity in KB cells and significantly sensitized the cells to CDDP. Treatment of KB cells with H-7 induced a dose-dependent depletion of intracellular glutathione (GSH) levels. These results suggest that the decreased GSH content induced by H-7 may be involved in sensitizing KB cells to CDDP.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Noda I, Saito H, Tanaka N, Sugimoto C and Fujieda S: Enhancement of sensitivity to CDDP in human pharyngeal carcinoma cells by H-7, a protein kinase inhibitor. Oncol Rep 4: 579-582, 1997.
APA
Noda, I., Saito, H., Tanaka, N., Sugimoto, C., & Fujieda, S. (1997). Enhancement of sensitivity to CDDP in human pharyngeal carcinoma cells by H-7, a protein kinase inhibitor. Oncology Reports, 4, 579-582. https://doi.org/10.3892/or.4.3.579
MLA
Noda, I., Saito, H., Tanaka, N., Sugimoto, C., Fujieda, S."Enhancement of sensitivity to CDDP in human pharyngeal carcinoma cells by H-7, a protein kinase inhibitor". Oncology Reports 4.3 (1997): 579-582.
Chicago
Noda, I., Saito, H., Tanaka, N., Sugimoto, C., Fujieda, S."Enhancement of sensitivity to CDDP in human pharyngeal carcinoma cells by H-7, a protein kinase inhibitor". Oncology Reports 4, no. 3 (1997): 579-582. https://doi.org/10.3892/or.4.3.579