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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1997 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 4 Issue 5

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Article

Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II

  • Authors:
    • K Himei
    • M Kuroda
    • D StClair
    • M Urano
    • T Yoshino
    • I Sakuma
    • T Akagi
    • J Asaumi
    • I Joja
    • Y Hiraki

  • View Affiliations / Copyright

    Affiliations: OKAYAMA UNIV,DEPT RADIOL,SCH MED,OKAYAMA 700,JAPAN. UNIV KENTUCKY,GRAD CTR TOXICOL,LEXINGTON,KY 40536. YAMANOUE HOSP,SHIZUOKA 42401,JAPAN.
  • Pages: 937-940
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/or.4.5.937
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Abstract

The tumor metastatic ability and tumorigenicity of the mouse fibrosarcoma cell line (FSa-II) were significantly reduced due to overexpression of manganese superoxide dismutase (MnSOD) as reported previously. We investigated changes in the in vitro basic character of FSa-II cells transfected with the human MnSOD cDNA which was employed in the previous studies. FSa-II and the control vector-transfected cell line NEO, had no detectable MnSOD activity. SOD-H, into which MnSOD cDNA was transfected, is the cell line with high MnSOD activity. The malignant phenotype, characterized by serum-independence, was suppressed with elevated MnSOD activity. A quantitative comparison of transferrin receptor (TfR) by flow cytometry showed the amount of TfR on the membrane of SOD-H cells to be significantly less than that on the membrane of NEO cells. The amount of CD44 expression on SOD-H cells was almost the same as that on NEO cells. The results of this study suggest that the overexpression of MnSOD is related to suppression of the malignant phenotype and that changes of iron metabolism may play an important role in this process.

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Copy and paste a formatted citation
Spandidos Publications style
Himei K, Kuroda M, StClair D, Urano M, Yoshino T, Sakuma I, Akagi T, Asaumi J, Joja I, Hiraki Y, Hiraki Y, et al: Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II. Oncol Rep 4: 937-940, 1997.
APA
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I. ... Hiraki, Y. (1997). Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II. Oncology Reports, 4, 937-940. https://doi.org/10.3892/or.4.5.937
MLA
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I., Akagi, T., Asaumi, J., Joja, I., Hiraki, Y."Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II". Oncology Reports 4.5 (1997): 937-940.
Chicago
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I., Akagi, T., Asaumi, J., Joja, I., Hiraki, Y."Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II". Oncology Reports 4, no. 5 (1997): 937-940. https://doi.org/10.3892/or.4.5.937
Copy and paste a formatted citation
x
Spandidos Publications style
Himei K, Kuroda M, StClair D, Urano M, Yoshino T, Sakuma I, Akagi T, Asaumi J, Joja I, Hiraki Y, Hiraki Y, et al: Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II. Oncol Rep 4: 937-940, 1997.
APA
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I. ... Hiraki, Y. (1997). Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II. Oncology Reports, 4, 937-940. https://doi.org/10.3892/or.4.5.937
MLA
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I., Akagi, T., Asaumi, J., Joja, I., Hiraki, Y."Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II". Oncology Reports 4.5 (1997): 937-940.
Chicago
Himei, K., Kuroda, M., StClair, D., Urano, M., Yoshino, T., Sakuma, I., Akagi, T., Asaumi, J., Joja, I., Hiraki, Y."Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II". Oncology Reports 4, no. 5 (1997): 937-940. https://doi.org/10.3892/or.4.5.937
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