Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma.

  • Authors:
    • K Sato
    • M Tanaka
    • T Kusaba
    • H Fukuda
    • K Tanikawa
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.355
  • Pages: 355-363
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Abstract

We demonstrated immunohistochemical staining of a-fetoprotein (AFP) in small hepatocellular carcinoma (HCC). Fifty-six patients with HCC less than 2 cm in diameter were studied. Twenty-five HCCs (44.6%) were positive for AFP-staining. The positive rate of AFP-staining in HCC tissue was higher in the patients with serum AFP concentration above 20 ng/ml than that of the patients with below 20 ng/ml. AFP-staining was demonstrated on the rough endoplasmic reticulum of HCC cells by immuno-electron microscopy. AFP-staining of tissue specimens obtained by fine needle biopsy is useful in the histologic diagnosis of HCC.

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Mar-Apr 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sato K, Tanaka M, Kusaba T, Fukuda H and Tanikawa K: Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma.. Oncol Rep 5: 355-363, 1998.
APA
Sato, K., Tanaka, M., Kusaba, T., Fukuda, H., & Tanikawa, K. (1998). Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma.. Oncology Reports, 5, 355-363. https://doi.org/10.3892/or.5.2.355
MLA
Sato, K., Tanaka, M., Kusaba, T., Fukuda, H., Tanikawa, K."Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma.". Oncology Reports 5.2 (1998): 355-363.
Chicago
Sato, K., Tanaka, M., Kusaba, T., Fukuda, H., Tanikawa, K."Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma.". Oncology Reports 5, no. 2 (1998): 355-363. https://doi.org/10.3892/or.5.2.355