search button

Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.

  • Authors:
    • K Tanimoto
    • S M Akbar
    • Y Yamauchi
    • K Michitaka
    • N Horiike
    • M Onji

  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/or.5.4.805
  • Pages: 805-814
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Metallothionein (MT), an oncofocal gene product was strongly expressed in 35%-95% of hepatocytes in hepatocellular carcinoma (HCC) and MT-positive hepatocytes were localized mainly in the non-cancerous cirrhotic nodules but not in malignant hepatocytes. On the other hand, <10% hepatocytes showed weak staining for MT in chronic hepatitis and cirrhosis of liver. Strong expressions of MT in non-cancerous cirrhotic nodule in HCC and low expressions in liver cirrhosis without HCC indicate a relationship between malignant transformation of hepatocytes and the expression of MT.

Related Articles

Journal Cover

Jul-Aug 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Tanimoto K, Akbar S, Yamauchi Y, Michitaka K, Horiike N and Onji M: Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.. Oncol Rep 5: 805-814, 1998.
APA
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., & Onji, M. (1998). Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.. Oncology Reports, 5, 805-814. https://doi.org/10.3892/or.5.4.805
MLA
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., Onji, M."Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.". Oncology Reports 5.4 (1998): 805-814.
Chicago
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., Onji, M."Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.". Oncology Reports 5, no. 4 (1998): 805-814. https://doi.org/10.3892/or.5.4.805