search button

Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.

  • Authors:
    • T Tokunaga
    • H Kijima
    • Y Oshika
    • Y Fukushima
    • Y Abe
    • Y Ohnishi
    • H Yamazaki
    • T Tsuchida
    • H Makuuchi
    • N Tamaoki
    • Y Ueyama
    • M Nakamura

  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/or.5.5.1115
  • Pages: 1115-1123
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Xenografted neoplastic tissues are often utilized to study biology of human cancer. We studied isoform pattern (VEGF206, VEGF189, VEGF165, VEGF121) of an angiogenic factor VEGF in both esophageal primary cancers and cancer xenografts by RT-PCR analysis. Eighteen of 19 (95%) xenografts showed the cell associated aberrant isoform of VEGF189 at a significantly higher incidence than 19 of 31 (61%) primary cancers (P=0.009, Fisher's exact test). These observations suggested that the aberrant isoform of VEGF189 mRNA affects the xenotransplantability of human esophageal cancer.

Related Articles

Journal Cover

Sep-Oct 1998
Volume 5 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Tokunaga T, Kijima H, Oshika Y, Fukushima Y, Abe Y, Ohnishi Y, Yamazaki H, Tsuchida T, Makuuchi H, Tamaoki N, Tamaoki N, et al: Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.. Oncol Rep 5: 1115-1123, 1998.
APA
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y. ... Nakamura, M. (1998). Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.. Oncology Reports, 5, 1115-1123. https://doi.org/10.3892/or.5.5.1115
MLA
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y., Yamazaki, H., Tsuchida, T., Makuuchi, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.". Oncology Reports 5.5 (1998): 1115-1123.
Chicago
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y., Yamazaki, H., Tsuchida, T., Makuuchi, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.". Oncology Reports 5, no. 5 (1998): 1115-1123. https://doi.org/10.3892/or.5.5.1115