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Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.

  • Authors:
    • A Tada
    • T Nishihara
    • H Kato

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  • Published online on: September 1, 1998     https://doi.org/10.3892/or.5.5.1137
  • Pages: 1137-1177
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Abstract

Bone morphogenetic protein 2 (BMP2) is a member of the transforming growth factor beta (TGFbeta) superfamily. Here we report a biological function of BMP2. Treatment of human lung carcinoma cell line, A549 cells with BMP2 resulted in inhibition of A549 cell growth in anchorage-dependent and independent growth conditions. Furthermore, BMP2 induced microfilament organization restoration in A549 cells. These changes were also observed in TGFbeta1-treated A549 cells. BMP2 and TGFbeta1 additionally suppressed the transformed phenotypes and restored actin microfilaments in A549 cells. In contrast, activin A, another member of the TGF superfamily did not induce these phenomena. It was also noted that the development of the microfilaments is almost proportional to the extent of the inhibition of cell growth in our system.

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Sep-Oct 1998
Volume 5 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Tada A, Nishihara T and Kato H: Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.. Oncol Rep 5: 1137-1177, 1998.
APA
Tada, A., Nishihara, T., & Kato, H. (1998). Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.. Oncology Reports, 5, 1137-1177. https://doi.org/10.3892/or.5.5.1137
MLA
Tada, A., Nishihara, T., Kato, H."Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.". Oncology Reports 5.5 (1998): 1137-1177.
Chicago
Tada, A., Nishihara, T., Kato, H."Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.". Oncology Reports 5, no. 5 (1998): 1137-1177. https://doi.org/10.3892/or.5.5.1137