search button

Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.

  • Authors:
    • A Goto
    • K Shomori
    • T Ohkumo
    • F Tanaka
    • K Sato
    • H Ito

  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/or.6.2.335
  • Pages: 335-344
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We examined the role of the p53 gene in hyperthermia-induced apoptosis using three human gastric carcinoma cell lines, MKN-28 (carrying mutated type p53 gene), MKN-74 (wild-type), and KATO-III (complete deletion). The results indicate that i) long-term hyperthermia causes necrosis, and short-term treatment induces apoptosis in a gradual time dependent fashion, ii) hyperthermia-triggered apoptosis can occur both in a p53 gene-dependent and -independent manner, and iii) up-regulation of Hsp70 might enhance the function of wild-type p53 protein in hyperthermia-induced apoptosis.

Related Articles

Journal Cover

Mar-Apr 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Goto A, Shomori K, Ohkumo T, Tanaka F, Sato K and Ito H: Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.. Oncol Rep 6: 335-344, 1999.
APA
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., & Ito, H. (1999). Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.. Oncology Reports, 6, 335-344. https://doi.org/10.3892/or.6.2.335
MLA
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., Ito, H."Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.". Oncology Reports 6.2 (1999): 335-344.
Chicago
Goto, A., Shomori, K., Ohkumo, T., Tanaka, F., Sato, K., Ito, H."Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines.". Oncology Reports 6, no. 2 (1999): 335-344. https://doi.org/10.3892/or.6.2.335