Structure and expression of variant BRCA2a lacking the transactivation domain.

Zou,J P; Hirose,Y; Siddique,H; Rao,V N; Reddy,E S

doi:10.3892/or.6.2.437

Structure and expression of variant BRCA2a lacking the transactivation domain.

Authors:
- J P Zou
- Y Hirose
- H Siddique
- V N Rao
- E S Reddy
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Affiliations: Division of Cancer Genetics, Department of Human Genetics, MS 481, Allegheny University of the Health Sciences, Broad and Vine, Philadelphia, PA 19102, USA.
Published online on: March 1, 1999 https://doi.org/10.3892/or.6.2.437
Pages: 437-477

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Abstract

BRCA1 and BRCA2 are tumor suppressor genes shown to be involved in 90% of familial breast cancers and also known to be involved in ovarian and prostate cancers. Both BRCA1 and BRCA2 gene products are regulated in a cell cycle-dependent manner and have potential transactivation function. Here, we show that BRCA2 undergoes differential splicing giving rise to a novel variant protein BRCA2a, lacking putative transcriptional activation domain. Both BRCA2a and BRCA2 are expressed at high levels in thymus and testis but moderate levels in mammary gland and prostate suggesting that BRCA2a and BRCA2 may have a role in the development and differentiation of these tissues.