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Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.

  • Authors:
    • R Swiercz
    • E Skrzypczak-Jankun
    • M M Merrell
    • S H Selman
    • J Jankun

  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/or.6.3.523
  • Pages: 523-529
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Abstract

We hypothesize that tumor angiogenesis can be limited by the reduction of enzymatic activity of the urokinase type plasminogen activator. The proposed mechanism is elimination of proteolytic activity by the advancing tip of capillaries which utilize proteolysis to produce space needed for vessel expansion. To test our hypothesis, we have investigated the angiostatic activity of synthetic low molecular weight inhibitors of urokinase: amiloride, benzamidine, EGCG, B428, and B623 using the chicken embryo corioallantoic membrane (CAM) model. We found that all tested inhibitors of urokinase cause a significant reduction of angiogenesis.

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May-Jun 1999
Volume 6 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Swiercz R, Skrzypczak-Jankun E, Merrell M, Selman S and Jankun J: Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.. Oncol Rep 6: 523-529, 1999.
APA
Swiercz, R., Skrzypczak-Jankun, E., Merrell, M., Selman, S., & Jankun, J. (1999). Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.. Oncology Reports, 6, 523-529. https://doi.org/10.3892/or.6.3.523
MLA
Swiercz, R., Skrzypczak-Jankun, E., Merrell, M., Selman, S., Jankun, J."Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.". Oncology Reports 6.3 (1999): 523-529.
Chicago
Swiercz, R., Skrzypczak-Jankun, E., Merrell, M., Selman, S., Jankun, J."Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.". Oncology Reports 6, no. 3 (1999): 523-529. https://doi.org/10.3892/or.6.3.523