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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 1999 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.

  • Authors:
    • C Gao
    • R Ohashi
    • H Pu
    • Y Inoue
    • T Tsuji
    • M Miyazaki
    • M Namba

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700-8558, Japan.
  • Pages: 1267-1338
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/or.6.6.1267
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Abstract

The structural abnormalities of the p53 gene have frequently been detected in hepatocellular carcinomas (HCCs). To ascertain whether or not functional inactivation of this gene also occurs in HCCs, the transactivation of p53 gene products in 11 HCC cell lines maintained in our laboratory and 26 HCC surgical specimens was examined by yeast functional assay (functional analysis of separated alleles in yeast: FASAY), which determines the functional status of the individual p53 alleles. The p53 gene product was inactivated in 8 of 11 (72.7%) HCC cell lines and in 12 of 26 (46.2%) HCC surgical specimens. The inactivation frequency of the gene was 37.5%, 36.4%, and 71.4% in well, moderately, and poorly differentiated HCCs, respectively. In HCC surgical specimens larger than 5 cm in diameter, the inactivation frequency was 83.3% while in those smaller than 2. 5 cm, it was 14.3%. These results show that functional inactivation of p53 gene products often occurs in HCCs and that the inactivation frequency of the gene in HCCs is well correlated with differentiation degree and tumor size, suggesting that the inactivation of p53 gene products plays a role in progression from well to poorly differentiated HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Gao C, Ohashi R, Pu H, Inoue Y, Tsuji T, Miyazaki M and Namba M: Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.. Oncol Rep 6: 1267-1338, 1999.
APA
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., & Namba, M. (1999). Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.. Oncology Reports, 6, 1267-1338. https://doi.org/10.3892/or.6.6.1267
MLA
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., Namba, M."Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.". Oncology Reports 6.6 (1999): 1267-1338.
Chicago
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., Namba, M."Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.". Oncology Reports 6, no. 6 (1999): 1267-1338. https://doi.org/10.3892/or.6.6.1267
Copy and paste a formatted citation
x
Spandidos Publications style
Gao C, Ohashi R, Pu H, Inoue Y, Tsuji T, Miyazaki M and Namba M: Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.. Oncol Rep 6: 1267-1338, 1999.
APA
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., & Namba, M. (1999). Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.. Oncology Reports, 6, 1267-1338. https://doi.org/10.3892/or.6.6.1267
MLA
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., Namba, M."Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.". Oncology Reports 6.6 (1999): 1267-1338.
Chicago
Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., Namba, M."Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.". Oncology Reports 6, no. 6 (1999): 1267-1338. https://doi.org/10.3892/or.6.6.1267
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