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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 1999 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov-Dec 1999 Volume 6 Issue 6

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Article

Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.

  • Authors:
    • M Indinnimeo
    • C Cicchini
    • A Stazi
    • E Giarnieri
    • M R Limiti
    • C Ghini
    • A Vecchione

  • View Affiliations / Copyright

    Affiliations: I Clinica Chirurgica-Policlinico <Umberto I>, Universita di Roma <La Sapienza>, I-00161 Roma, Italy.
  • Pages: 1353-1359
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/or.6.6.1353
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Abstract

To improve life expectancy prognostic factors other than TNM have been investigated. It is thought that nm23 protein may play a specific biological role in suppressing tumor metastasis. The purpose of this study was to elucidate the clinical significance of nm23 expression in human anal canal carcinoma. Immunostaining using anti-nm23 monoclonal antibody was performed in 22 anal canal tumors. The results were correlated with clinicopathological variables. Six cases out of 22 (27.3%) were nm23-positive. Significant association was found between nm23-H1 expression and depth of invasion, lymph node involvement and prognosis (p<0.05). There was no significant association between nm23-H1 expression, histologic type and age of the patients. nm23-H1 expression was not seen in our cases with metastasis and this may be related to nm23 gene alterations not being detectable by the monoclonal antibody used or to the presence of a subset of tumors in which nm23 gene abnormalities had not yet occurred at the time of tumor excision or biopsy. Overexpression of nm23-H1 protein in anal canal carcinoma may have implications for its metastatic potential. nm23-H1 expression would provide a more accurate evaluation of outcome for individual patients and thus improve treatment planning.

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Copy and paste a formatted citation
Spandidos Publications style
Indinnimeo M, Cicchini C, Stazi A, Giarnieri E, Limiti M, Ghini C and Vecchione A: Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.. Oncol Rep 6: 1353-1359, 1999.
APA
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., & Vecchione, A. (1999). Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.. Oncology Reports, 6, 1353-1359. https://doi.org/10.3892/or.6.6.1353
MLA
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., Vecchione, A."Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.". Oncology Reports 6.6 (1999): 1353-1359.
Chicago
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., Vecchione, A."Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.". Oncology Reports 6, no. 6 (1999): 1353-1359. https://doi.org/10.3892/or.6.6.1353
Copy and paste a formatted citation
x
Spandidos Publications style
Indinnimeo M, Cicchini C, Stazi A, Giarnieri E, Limiti M, Ghini C and Vecchione A: Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.. Oncol Rep 6: 1353-1359, 1999.
APA
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., & Vecchione, A. (1999). Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.. Oncology Reports, 6, 1353-1359. https://doi.org/10.3892/or.6.6.1353
MLA
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., Vecchione, A."Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.". Oncology Reports 6.6 (1999): 1353-1359.
Chicago
Indinnimeo, M., Cicchini, C., Stazi, A., Giarnieri, E., Limiti, M., Ghini, C., Vecchione, A."Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma.". Oncology Reports 6, no. 6 (1999): 1353-1359. https://doi.org/10.3892/or.6.6.1353
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