Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.

Deguchi,M; Matsumoto,Y; Ishiko,O; Ogita,S

doi:10.3892/or.7.3.651

Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.

Authors:
- M Deguchi
- Y Matsumoto
- O Ishiko
- S Ogita
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Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical College, Kihoku Hospital, Katsuragi, Wakayama 649-7113, Japan.
Published online on: May 1, 2000 https://doi.org/10.3892/or.7.3.651
Pages: 651-655

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Abstract

Twenty-five patients with ovarian clear cell carcinoma (CC-Ca) were enrolled in this study, and tumor cell expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) was investigated, and correlated with the microvessel count (MVC) and the impact of complication endometriosis. Expression of VEGF was strongly positive in 16 cases, weakly positive in 6 cases, and negative in 3 cases. Expression of PD-ECGF was strongly positive in 11 cases, weakly positive in 6 cases, and negative in 8 cases. VEGF expression and the MVC were significantly correlated (p<0.01), and there were no correlations among complication by endometriosis, expression of VEGF, expression of PD-ECGF, and MVC.