Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.

  • Authors:
    • U Reinhold
    • S Ugurel
    • W Tilgen
    • M M Kadiata
    • E Olivares
    • A B Nadi
    • W J Malaisse
  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/or.7.5.1093
  • Pages: 1093-1100
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The ester 2-deoxy-D-glucose tetraacetate (2-DOGTA) was recently shown to display cytostatic and cytotoxic activity in various lines of tumoral cells. In the present work, it was found to inhibit cell growth and confer chemosensitivity to cisplatin in two lines of human melanoma cells, poorly responsive to cisplatin. The inhibition of cell growth by 2-DOGTA was apparently not attributable to alteration of either D-glucose utilization or oxidation in these melanoma cell lines. In freshly isolated human melanoma cells, 2-DOGTA also inhibited cell growth, even in cells resistant to standard chemotherapeutic agents, such as temozolomide, cisplatin and/or vindesine. It is proposed, therefore, that 2-DOGTA should be further investigated for the treatment of melanoma patients, whether alone or in combination with known chemotherapeutic agents.

Related Articles

Journal Cover

Sep-Oct 2000
Volume 7 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Reinhold U, Ugurel S, Tilgen W, Kadiata M, Olivares E, Nadi A and Malaisse W: Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.. Oncol Rep 7: 1093-1100, 2000.
APA
Reinhold, U., Ugurel, S., Tilgen, W., Kadiata, M., Olivares, E., Nadi, A., & Malaisse, W. (2000). Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.. Oncology Reports, 7, 1093-1100. https://doi.org/10.3892/or.7.5.1093
MLA
Reinhold, U., Ugurel, S., Tilgen, W., Kadiata, M., Olivares, E., Nadi, A., Malaisse, W."Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.". Oncology Reports 7.5 (2000): 1093-1100.
Chicago
Reinhold, U., Ugurel, S., Tilgen, W., Kadiata, M., Olivares, E., Nadi, A., Malaisse, W."Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.". Oncology Reports 7, no. 5 (2000): 1093-1100. https://doi.org/10.3892/or.7.5.1093