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The time of tumor cell division and death depends on the site of growth.

  • Authors:
    • L L Colombo
    • E O Mazzoni
    • R P Meiss

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  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1363
  • Pages: 1363-1369
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Abstract

We show here, for the first time, in two very different murine tumors, a mammary one (ectoderm) and a lung one (endoderm), that: tumors have day/night differences of spontaneous apoptosis additional to the well-known circadian rhythm of mitosis. The times of maximal and minimal mitosis and apoptosis changed for a tumor cell line when growing in different organs (as metastasis) or anatomical sites. Both tumor lines, have identical circadian curves when growing in a specific organ or anatomical site. The peaks of apoptosis match with the valleys of mitosis and vice versa.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Colombo L, Mazzoni E and Meiss R: The time of tumor cell division and death depends on the site of growth.. Oncol Rep 7: 1363-1369, 2000.
APA
Colombo, L., Mazzoni, E., & Meiss, R. (2000). The time of tumor cell division and death depends on the site of growth.. Oncology Reports, 7, 1363-1369. https://doi.org/10.3892/or.7.6.1363
MLA
Colombo, L., Mazzoni, E., Meiss, R."The time of tumor cell division and death depends on the site of growth.". Oncology Reports 7.6 (2000): 1363-1369.
Chicago
Colombo, L., Mazzoni, E., Meiss, R."The time of tumor cell division and death depends on the site of growth.". Oncology Reports 7, no. 6 (2000): 1363-1369. https://doi.org/10.3892/or.7.6.1363