Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma

  • Authors:
    • Shinsuke Takeno
    • Tsuyoshi Noguchi
    • Ryuichi Kikuchi
    • Shinsuke Wada
    • Tetsuro Sato
    • Yuzo Uchida
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/or.8.3.585
  • Pages: 585-590
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Abstract

It is reported that macrophages and CD4+ or CD8+ cytotoxic T cells have an important role in the suppression of cancer progression. The aim of this study was to clarify these immune responses in patients with esophageal cancer. We enrolled 28 patients with pT2 esophageal cancer that had been resected without preoperative adjuvant therapy. The correlations between the numbers of infiltrating CD4+, CD8+ and CD68+ cells, the expression of heat shock protein 70 (hsp70) and a variety of clinicopathologic factors were analyzed. The numbers of CD8+ T cells and CD68+ macrophages showed a significant positive correlation with tumor diameter (p=0.01, p=0.037) and the expression of hsp70 (p=0.01, p=0.02) and a negative correlation with lymph node metastasis (p=0.0079, p<0.0001). The expression of hsp70 exhibited a negative correlation with lymph node metastasis (p=0.023). CD8+ T cells and CD68+ macrophages might have a suppressive function against esophageal cancer progression. Our results suggested that hsp70 might play an important role in the presentation of tumor specific antigens.

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May-June 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takeno S, Noguchi T, Kikuchi R, Wada S, Sato T and Uchida Y: Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma. Oncol Rep 8: 585-590, 2001.
APA
Takeno, S., Noguchi, T., Kikuchi, R., Wada, S., Sato, T., & Uchida, Y. (2001). Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma. Oncology Reports, 8, 585-590. https://doi.org/10.3892/or.8.3.585
MLA
Takeno, S., Noguchi, T., Kikuchi, R., Wada, S., Sato, T., Uchida, Y."Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma". Oncology Reports 8.3 (2001): 585-590.
Chicago
Takeno, S., Noguchi, T., Kikuchi, R., Wada, S., Sato, T., Uchida, Y."Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma". Oncology Reports 8, no. 3 (2001): 585-590. https://doi.org/10.3892/or.8.3.585