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Molecular analysis of p53 tumor-suppressor gene and microsatellites in preneoplastic and neoplastic lesions of the colon and esophagus

  • Authors:
    • Silvia Beatriz Copelli
    • Carla Mazzeo
    • Alejandra Gimenez
    • Claudia Casco
    • Roberto Meiss
    • Horacio Rubio
    • Alfredo Speroni
    • Silvia Vanzulli

  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.923
  • Pages: 923-929
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Abstract

Mutations in exons 4-8 of the p53 gene by the PCR-SSCP analysis in preneoplastic and neoplastic lesions of the colon (n=11) and esophagus (n=18) were screened. p53 overexpression by immunohistochemistry in 11 colonic lesions and 13 microsatellites, in all the patients (n=29), were also studied. A positive result concordancy between the three techniques was found in 1 adenoma and 2 adenocarcinomas of the colon, each with loss of heterozygocity of microsatellites. Metaplastic lesions of esophagus showed biallelic mutations and low frequency of microsatellite alterations. The relationship between genetic alterations in p53, microsatellites and type of colon and esophageal lesions is discussed.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Copelli SB, Mazzeo C, Gimenez A, Casco C, Meiss R, Rubio H, Speroni A and Vanzulli S: Molecular analysis of p53 tumor-suppressor gene and microsatellites in preneoplastic and neoplastic lesions of the colon and esophagus. Oncol Rep 8: 923-929, 2001.
APA
Copelli, S.B., Mazzeo, C., Gimenez, A., Casco, C., Meiss, R., Rubio, H. ... Vanzulli, S. (2001). Molecular analysis of p53 tumor-suppressor gene and microsatellites in preneoplastic and neoplastic lesions of the colon and esophagus. Oncology Reports, 8, 923-929. https://doi.org/10.3892/or.8.4.923
MLA
Copelli, S. B., Mazzeo, C., Gimenez, A., Casco, C., Meiss, R., Rubio, H., Speroni, A., Vanzulli, S."Molecular analysis of p53 tumor-suppressor gene and microsatellites in preneoplastic and neoplastic lesions of the colon and esophagus". Oncology Reports 8.4 (2001): 923-929.
Chicago
Copelli, S. B., Mazzeo, C., Gimenez, A., Casco, C., Meiss, R., Rubio, H., Speroni, A., Vanzulli, S."Molecular analysis of p53 tumor-suppressor gene and microsatellites in preneoplastic and neoplastic lesions of the colon and esophagus". Oncology Reports 8, no. 4 (2001): 923-929. https://doi.org/10.3892/or.8.4.923