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Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer

  • Authors:
    • Hirofumi Awata
    • Kazuo Hirose
    • Akio Yamaguchi

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  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.153
  • Pages: 153-158
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Abstract

Using the in situ DNA nick end-labeling method and immunohistochemistry, the indices of apoptosis (AI) and Ki-67 labeling index (LI) among 3 different portions within the tumor (the central surface vs. the lateral margin or deepest portion) were determined and compared in 14 superficial spreading type early gastric cancers. The AI was the lowest and the LI remained high in the lateral margin compared with the central surface, whereas the AI remained high and the LI was the lowest in the deepest portion. This heterogeneity of apoptosis and proliferation within the tumor might be related to the predominantly horizontal growth of superficial spreading type early gastric cancer.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Awata H, Hirose K and Yamaguchi A: Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer. Oncol Rep 9: 153-158, 2002.
APA
Awata, H., Hirose, K., & Yamaguchi, A. (2002). Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer. Oncology Reports, 9, 153-158. https://doi.org/10.3892/or.9.1.153
MLA
Awata, H., Hirose, K., Yamaguchi, A."Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer". Oncology Reports 9.1 (2002): 153-158.
Chicago
Awata, H., Hirose, K., Yamaguchi, A."Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer". Oncology Reports 9, no. 1 (2002): 153-158. https://doi.org/10.3892/or.9.1.153