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Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy

  • Authors:
    • Masashi Seto
    • Takashi Yamazaki
    • Jun Sonoda
    • Akihiko Matsumine
    • Yoshitaka Shinto
    • Atsumasa Uchida

  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/or.9.2.337
  • Pages: 337-340
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We evaluated the effect of gene therapy in the murine osteosarcoma cell line, LM8, which preferentially metastasizes to the lungs. LM8 cells were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli β-galactosidase (lacZ). We investigated the cytotoxicity of LM8 cells bearing an HSV-tk gene after treatment with ganciclovir (GCV). LM8 cells bearing an HSV-tk gene were more sensitive than non-transduced cells. The remarkable inhibition of tumor growth and pulmonary metastases was confirmed in vivo. Our findings indicated that GCV kills tumor cells transduced with HSV-tk in vitro and in vivo.

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March-April 2002
Volume 9 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Seto M, Yamazaki T, Sonoda J, Matsumine A, Shinto Y and Uchida A: Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy. Oncol Rep 9: 337-340, 2002.
APA
Seto, M., Yamazaki, T., Sonoda, J., Matsumine, A., Shinto, Y., & Uchida, A. (2002). Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy. Oncology Reports, 9, 337-340. https://doi.org/10.3892/or.9.2.337
MLA
Seto, M., Yamazaki, T., Sonoda, J., Matsumine, A., Shinto, Y., Uchida, A."Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy". Oncology Reports 9.2 (2002): 337-340.
Chicago
Seto, M., Yamazaki, T., Sonoda, J., Matsumine, A., Shinto, Y., Uchida, A."Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy". Oncology Reports 9, no. 2 (2002): 337-340. https://doi.org/10.3892/or.9.2.337