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Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer

  • Authors:
    • Konosuke Kiuchi
    • Takashi Ishikawa
    • Yohei Hamaguchi
    • Nobuyoshi Momiyama
    • Satoshi Hasegawa
    • Akira Ishiyama
    • Toshiro Kono
    • Takako Doi
    • Takashi Chishima
    • Hiroshi Shimada

  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/or.9.3.595
  • Pages: 595-598
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Abstract

Bone resorption markers have become available for the diagnosis of bone metastasis. We evaluated cross-linked collagen C-and N-telopeptides (ICTP and NTx) in diagnosing bone metastasis from breast cancer. For a threshold of 4.5 ng/ml of 1CTP and 55.0 pmol BCE/μmol of NTx, bone metastasis could be predicted with an accuracy of 84% and 63%, respectively. All the patients who had metastatic lesions, but showed lower than 4.5 ng/ml of ICTP, had a solitary lesion of bone metastasis. Although ICTP is not sensitive enough to detect an early stage of bone metastasis, it is a better biochemical marker than NTx for detecting bone metastasis from breast cancer.

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May-June 2002
Volume 9 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Kiuchi K, Ishikawa T, Hamaguchi Y, Momiyama N, Hasegawa S, Ishiyama A, Kono T, Doi T, Chishima T, Shimada H, Shimada H, et al: Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer. Oncol Rep 9: 595-598, 2002.
APA
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A. ... Shimada, H. (2002). Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer. Oncology Reports, 9, 595-598. https://doi.org/10.3892/or.9.3.595
MLA
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A., Kono, T., Doi, T., Chishima, T., Shimada, H."Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer". Oncology Reports 9.3 (2002): 595-598.
Chicago
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A., Kono, T., Doi, T., Chishima, T., Shimada, H."Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer". Oncology Reports 9, no. 3 (2002): 595-598. https://doi.org/10.3892/or.9.3.595