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Restoration of estrogen responsiveness by blocking the HER-2/neu pathway

  • Authors:
    • Lois Witters
    • Linda Engle
    • Allan Lipton

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  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1163
  • Pages: 1163-1166
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Abstract

HER-2/neu gene amplification or protein overexpression is evident in 20-30% of primary breast cancers. Its amplification correlates with poor prognosis. There appears to be an association between HER-2/neu overexpression and estrogen independence. The MCF-7 human breast carcinoma cell line is estrogen-dependent and sensitive to the anti-estrogen, tamoxifen (TAM). This line, when transfected with the HER-2/neu gene, becomes estrogen-independent and resistant to TAM. Blockade of the HER-2/neu receptor with 1-5 nM of the humanized HER-2/neu antibody, Herceptin, restored estrogen, as well as TAM, sensitivity. These results suggest that Herceptin or similar drugs may restore estrogen sensitivity and the administration of a HER-2/neu inhibitor with an anti-estrogen to premenopausal patients should be considered.

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November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Witters L, Engle L and Lipton A: Restoration of estrogen responsiveness by blocking the HER-2/neu pathway. Oncol Rep 9: 1163-1166, 2002.
APA
Witters, L., Engle, L., & Lipton, A. (2002). Restoration of estrogen responsiveness by blocking the HER-2/neu pathway. Oncology Reports, 9, 1163-1166. https://doi.org/10.3892/or.9.6.1163
MLA
Witters, L., Engle, L., Lipton, A."Restoration of estrogen responsiveness by blocking the HER-2/neu pathway". Oncology Reports 9.6 (2002): 1163-1166.
Chicago
Witters, L., Engle, L., Lipton, A."Restoration of estrogen responsiveness by blocking the HER-2/neu pathway". Oncology Reports 9, no. 6 (2002): 1163-1166. https://doi.org/10.3892/or.9.6.1163