Open Access

The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines

  • Authors:
    • Joanna Wietrzyk
    • Beata Filip
    • Magdalena Milczarek
    • Dagmara Klopotowska
    • Magdalena Maciejewska
    • Krystyna Dabrowska
    • Aneta Kurzepa
    • Stanislaw Dzimira
    • Janusz Madej
    • Andrzej Kutner
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/or_00000094
  • Pages: 941-952
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Abstract

Integrins are cell-surface receptors engaged in important cancer invasion processes, such as adhesion, migration, proliferation and differentiation. The aim of this study was to evaluate the effect of 1,25-dihydroxyvitamin D3 (calcitriol) and its metabolite 1,24-dihydroxyvitamin D3 (PRI-2191) on αvβ3 integrin expression in various cancer cell lines. The expression levels of the β3 and αv integrins were reduced only in the WEHI-3 and LLC cell lines by the two compounds. Calcitriol or PRI-2191 treatment caused differentiation of WEHI-3 mouse leukemia cells, but apoptosis of LLC cells. WEHI-3 and LLC cells exposed to calcitriol or PRI-2191 lost their migratory and adhesive potentials. The inhibition of migratory potential was higher in the LLC cells than in the WEHI-3 cells and appeared to correlate with the increased down-regulation of αvβ3 integrin by calcitriol or PRI-2191. The observed in vivo effects (antitumor and antimetastatic) in mice bearing subcutaneously transplanted LLC cancer are possibly associated with inhibited migratory potential as a consequence of the lowered integrin expression caused by calcitriol or PRI-2191.

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October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wietrzyk J, Filip B, Milczarek M, Klopotowska D, Maciejewska M, Dabrowska K, Kurzepa A, Dzimira S, Madej J, Kutner A, Kutner A, et al: The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncol Rep 20: 941-952, 2008.
APA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K. ... Kutner, A. (2008). The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncology Reports, 20, 941-952. https://doi.org/10.3892/or_00000094
MLA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20.4 (2008): 941-952.
Chicago
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20, no. 4 (2008): 941-952. https://doi.org/10.3892/or_00000094