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Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy

  • Authors:
    • Jian Zhang
    • Yu Gan
    • Jinfa Gu
    • Jingying Hu
    • Xinyuan Liu
    • Xintai Zhao

  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/or_00000106
  • Pages: 1035-1040
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We previously demonstrated that hepatocellular carcinoma suppressor 1 (HCCS1) exerts potent anti-tumor activity. In this study, we constructed a new dual tumor-targeting oncolytic adenovirus vector, PD55-HCCS1, in which E1A was driven by the promoter of progression elevated gene-3, which is hepatoma-specific, and a CMV-HCCS1 expression cassette replaced E1B55. The PD55-HCCS1-mediated selective expression of E1A and HCCS1 in hepatoma cells and tumor-selective cytotoxicity in vitro and in vivo demonstrated the strongest inhibition of BEL-7404 cell xenografts in nude mice among a number of control Ad vectors. These data indicated the efficacy and safety of the PD55-HCCS1 system for HCC treatment.

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Journal Cover

November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Zhang J, Gan Y, Gu J, Hu J, Liu X and Zhao X: Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy. Oncol Rep 20: 1035-1040, 2008.
APA
Zhang, J., Gan, Y., Gu, J., Hu, J., Liu, X., & Zhao, X. (2008). Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy. Oncology Reports, 20, 1035-1040. https://doi.org/10.3892/or_00000106
MLA
Zhang, J., Gan, Y., Gu, J., Hu, J., Liu, X., Zhao, X."Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy". Oncology Reports 20.5 (2008): 1035-1040.
Chicago
Zhang, J., Gan, Y., Gu, J., Hu, J., Liu, X., Zhao, X."Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy". Oncology Reports 20, no. 5 (2008): 1035-1040. https://doi.org/10.3892/or_00000106