Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/β-catenin complex

  • Authors:
    • Ha Na Choi
    • Kyung Ryoul Kim
    • Ji Hyun Lee
    • Ho Sung Park
    • Kyu Yun Jang
    • Myoung Ja Chung
    • Si Eun Hwang
    • Hee Chul Yu
    • Woo Sung Moon
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000189
  • Pages: 57-63
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Abstract

Serum response factor (SRF) is a transcription factor that controls cell growth, differentiation, and tumor progression as well as muscle development and function. Reduced expression of cell adhesion molecules has been reported to be associated with tumor metastasis. The aim of this study was to evaluate the expression and a role of SRF in liver metastasis of primary colorectal carcinomas. We examined the expression of SRF, E-cadherin, and β-catenin by the use of immunochemical staining in 43 cases as a set of primary colorectal carcinomas and liver metastases. We also examined the role of SRF in colorectal carcinoma by overexpression of SRF in a colon cancer cell line. In metastatic carcinoma surgical samples, there was a marked increased expression of SRF as compared to expression in primary colorectal carcinoma surgical samples (P<0.05). E-cadherin expression was significantly decreased in metastatic liver carcinoma samples as compared to primary colorectal carcinoma samples (P<0.001). Frequent nuclear translocation of β-catenin protein in primary and metastatic carcinoma cells was observed. Overexpression of SRF in SW480 cells resulted in a decreased expression of E-cadherin and an increased expression of non-phosphorylated nuclear β-catenin. Overexpression of SRF in colorectal carcinoma cells enhanced cell motility and invasiveness. These results indicate that overexpression of SRF in colorectal carcinoma cells is associated with modulation of E-cadherin/β-catenin expression and may play an important role in colorectal cancer metastasis.

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January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Choi HN, Kim KR, Lee JH, Park HS, Jang KY, Chung MJ, Hwang SE, Yu HC and Moon WS: Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/β-catenin complex. Oncol Rep 21: 57-63, 2009.
APA
Choi, H.N., Kim, K.R., Lee, J.H., Park, H.S., Jang, K.Y., Chung, M.J. ... Moon, W.S. (2009). Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/β-catenin complex. Oncology Reports, 21, 57-63. https://doi.org/10.3892/or_00000189
MLA
Choi, H. N., Kim, K. R., Lee, J. H., Park, H. S., Jang, K. Y., Chung, M. J., Hwang, S. E., Yu, H. C., Moon, W. S."Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/β-catenin complex". Oncology Reports 21.1 (2009): 57-63.
Chicago
Choi, H. N., Kim, K. R., Lee, J. H., Park, H. S., Jang, K. Y., Chung, M. J., Hwang, S. E., Yu, H. C., Moon, W. S."Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/β-catenin complex". Oncology Reports 21, no. 1 (2009): 57-63. https://doi.org/10.3892/or_00000189