Open Access

Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma

  • Authors:
    • Nuo Yi
    • Qin-Ping Liao
    • Ting Li
    • Yan Xiong
  • View Affiliations

  • Published online on: June 1, 2009     https://doi.org/10.3892/or_00000370
  • Pages: 1421-1427
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Abstract

DKK1 is a negative regulator in the Wnt signal transduction pathway. It can inhibit the pathway's activation. Previous studies in some malignant tumors revealed the possibility that DKK1 is involved in tumorigenesis inducing abnormalities of the Wnt signal pathway. In this study, we showed that in benign and malignant endometrium, DKK1 exhibited novel expression profiles and invasiveness-related biology function: DKK1 was expressed in both glandular epithelium and matrix of two kinds of endometrium tissues and mostly distributed in the cytoplasm and epicytes of endometrial carcinoma (EC) Ishikawa cell line. DKK1 expression level in EC was significantly lower than that in benign endometrium. The expression correlated well with histology and clinical stage of EC. Exogenous DKK1 suppressed invasiveness of EC cells. Taken together, DKK1 is involved in genesis and early phase of EC by suppressing the invasiveness via the Wnt signal pathway. It shows promise as a biomarker for screening the progression of EC.

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Journal Cover

June 2009
Volume 21 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yi N, Liao Q, Li T and Xiong Y: Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma. Oncol Rep 21: 1421-1427, 2009.
APA
Yi, N., Liao, Q., Li, T., & Xiong, Y. (2009). Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma. Oncology Reports, 21, 1421-1427. https://doi.org/10.3892/or_00000370
MLA
Yi, N., Liao, Q., Li, T., Xiong, Y."Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma". Oncology Reports 21.6 (2009): 1421-1427.
Chicago
Yi, N., Liao, Q., Li, T., Xiong, Y."Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma". Oncology Reports 21, no. 6 (2009): 1421-1427. https://doi.org/10.3892/or_00000370