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Association of cellular localization of glycogen synthase kinase 3β in the digestive tract with cancer development

  • Authors:
    • Hiroshi Hirakawa
    • Toshiyuki Nakayama
    • Kenichiro Shibata
    • Ichiro Sekine
  • View Affiliations

  • Published online on: September 1, 2009     https://doi.org/10.3892/or_00000460
  • Pages: 481-485
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Abstract

Glycogen synthase kinase 3β (GSK-3β) is a multifunctional serine/threonine kinase involved in several signaling pathways. Recently, we reported the polarized localization of GSK-3β on the apical membrane of normal colon epithelium. To investigate the functions of this molecule, we studied stomach and colorectal cancer tissues. In normal simple columnar epithelium, GSK-3β was localized with tight junction-associated protein ZO-1 in a single line at the apical cell border. GSK-3β and ZO-1 were localized in the apical regions of tubular adenocarcinoma, similar to their localization in normal epithelium; however, their localization was different at the invasive front of the cancer and was found to be associated with lymphatic invasion. In signet-ring cell carcinoma of the stomach, the expression of these proteins was reduced and dot-like expression was observed in each cell of the signet-ring cell carcinoma. We speculated that GSK-3β is involved in glandular structure formation and that the non-apical localization of membrane-localized GSK-3β in tubular adenocarcinoma is associated with cancer development.

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September 2009
Volume 22 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hirakawa H, Nakayama T, Shibata K and Sekine I: Association of cellular localization of glycogen synthase kinase 3β in the digestive tract with cancer development. Oncol Rep 22: 481-485, 2009.
APA
Hirakawa, H., Nakayama, T., Shibata, K., & Sekine, I. (2009). Association of cellular localization of glycogen synthase kinase 3β in the digestive tract with cancer development. Oncology Reports, 22, 481-485. https://doi.org/10.3892/or_00000460
MLA
Hirakawa, H., Nakayama, T., Shibata, K., Sekine, I."Association of cellular localization of glycogen synthase kinase 3β in the digestive tract with cancer development". Oncology Reports 22.3 (2009): 481-485.
Chicago
Hirakawa, H., Nakayama, T., Shibata, K., Sekine, I."Association of cellular localization of glycogen synthase kinase 3β in the digestive tract with cancer development". Oncology Reports 22, no. 3 (2009): 481-485. https://doi.org/10.3892/or_00000460