A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data

  • Authors:
    • Jürgen Scheele
    • Faiz Niazi
    • Joachim Drevs
    • Klaus Diergarten
    • Papa Toure
  • View Affiliations

  • Published online on: October 1, 2009     https://doi.org/10.3892/or_00000512
  • Pages: 877-883
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Abstract

This pilot study of Auron Misheil Therapy (AMT) in women with advanced cervical cancer was an open-label, single arm study to collect initial safety, efficacy, and quality of life data. Fifteen women with stage IIIb or IVa cervical cancer were given twice daily intramuscular injections of AMT (insulin, chlorpheniramine and camomile extract) for 3 months. Objective tumor response was evaluated using CT scans and analyzing the data according to the WHO RECIST criteria. Clinical Benefit Response (CBR) was assessed using a composite score comprising Karnovsky performance status, pain intensity and body weight. Safety and tolerability parameters were monitored. Quality of life was evaluated using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC C-30). Eight out of 15 patients were rated as clinical responders (CBR) at 12 weeks. One patient had a partial response and 11 stable disease (WHO RECIST criteria). AMT was well tolerated. An initial analysis showed improvement in quality of life (EORTC C-30). Promising response rates, early indications of improved quality of life, and no significant safety issues mean that the second, randomized phase of the trial can be initiated with a longer treatment duration. Patients with advanced cervical cancer showed positive clinical responses to Auron Misheil Therapy. The treatment was well tolerated, with indications of improved quality of life.

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October 2009
Volume 22 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Scheele J, Niazi F, Drevs J, Diergarten K and Toure P: A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data. Oncol Rep 22: 877-883, 2009.
APA
Scheele, J., Niazi, F., Drevs, J., Diergarten, K., & Toure, P. (2009). A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data. Oncology Reports, 22, 877-883. https://doi.org/10.3892/or_00000512
MLA
Scheele, J., Niazi, F., Drevs, J., Diergarten, K., Toure, P."A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data". Oncology Reports 22.4 (2009): 877-883.
Chicago
Scheele, J., Niazi, F., Drevs, J., Diergarten, K., Toure, P."A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data". Oncology Reports 22, no. 4 (2009): 877-883. https://doi.org/10.3892/or_00000512