DNA oxidative damage of neoplastic rat liver lesions

  • Authors:
    • Barbara Marengo
    • Chiara De Ciusis
    • Roberta Ricciarelli
    • Paola Romano
    • Mario Passalacqua
    • Umberto M. Marinari
    • Maria A. Pronzato
    • Cinzia Domenicotti
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/or_00000756
  • Pages: 1241-1246
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hepatic lesions, experimentally-induced in Fisher 344 (F344) and Brown Norway (BN) rats, respectively, susceptible and resistant to liver carcinogenesis, progress differently to hepatocellular carcinoma (HCC). The mechanisms responsible for the acquisition of the resistant phenotype are not completely clear. Herein, we show that in F344 rats subjected to carcinogenic treatment, angiogenesis and DNA oxidation markers increase in preneoplastic and neoplastic liver lesions. On the contrary, in the HCCs of treated BN rats, angiogenesis and a minor DNA oxidation are accompanied by an attempt of tissue remodelling. This study suggests that DNA oxidation might be an important factor in the initiation and promotion of the events of hepatocarcinogenesis. On the other hand, the enhancement of GSH levels and the down-regulation of superoxide dismutase (SOD) expression in both rat strains suggest that antioxidant response is not involved in the acquisition of resistant phenotype.

Related Articles

Journal Cover

May 2010
Volume 23 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Marengo B, De Ciusis C, Ricciarelli R, Romano P, Passalacqua M, Marinari UM, Pronzato MA and Domenicotti C: DNA oxidative damage of neoplastic rat liver lesions. Oncol Rep 23: 1241-1246, 2010.
APA
Marengo, B., De Ciusis, C., Ricciarelli, R., Romano, P., Passalacqua, M., Marinari, U.M. ... Domenicotti, C. (2010). DNA oxidative damage of neoplastic rat liver lesions. Oncology Reports, 23, 1241-1246. https://doi.org/10.3892/or_00000756
MLA
Marengo, B., De Ciusis, C., Ricciarelli, R., Romano, P., Passalacqua, M., Marinari, U. M., Pronzato, M. A., Domenicotti, C."DNA oxidative damage of neoplastic rat liver lesions". Oncology Reports 23.5 (2010): 1241-1246.
Chicago
Marengo, B., De Ciusis, C., Ricciarelli, R., Romano, P., Passalacqua, M., Marinari, U. M., Pronzato, M. A., Domenicotti, C."DNA oxidative damage of neoplastic rat liver lesions". Oncology Reports 23, no. 5 (2010): 1241-1246. https://doi.org/10.3892/or_00000756