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AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion

  • Authors:
    • Junxia Zhang
    • Lei Han
    • Anling Zhang
    • Yingyi Wang
    • Xiao Yue
    • Yongping You
    • Peiyu Pu
    • Chunsheng Kang

  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/or_00000829
  • Pages: 65-72
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Abstract

Recent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFκB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFκB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.

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Journal Cover

July 2010
Volume 24 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Zhang J, Han L, Zhang A, Wang Y, Yue X, You Y, Pu P and Kang C: AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncol Rep 24: 65-72, 2010.
APA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y. ... Kang, C. (2010). AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion . Oncology Reports, 24, 65-72. https://doi.org/10.3892/or_00000829
MLA
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24.1 (2010): 65-72.
Chicago
Zhang, J., Han, L., Zhang, A., Wang, Y., Yue, X., You, Y., Pu, P., Kang, C."AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion ". Oncology Reports 24, no. 1 (2010): 65-72. https://doi.org/10.3892/or_00000829