Open Access

Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)

  • Authors:
    • Ritu Raina
    • Ravinder Bhatt
    • Arif Hussain
  • View Affiliations

  • Published online on: June 26, 2024     https://doi.org/10.3892/wasj.2024.260
  • Article Number: 45
  • Copyright : © Raina et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

One of the most extensively used herbal medicines is chrysin, a naturally occurring flavone commonly detected in several natural products, including propolis and honey. Due to its various biological properties, such as antioxidant, anti‑estrogenic, anti‑inflammatory, anti‑allergic, antibacterial and anticancer activities, chrysin has emerged as the leading contender for health benefits. Amongst the several pharmacological effects exhibited by chrysin, its anticancer activity is the most attractive. Several studies have demonstrated that chrysin suppresses tumor progression in cell lines and animal models by inducing apoptosis, disrupting the cell cycle and inhibiting migration without generating toxicity or undesired side‑effects in normal cells. Furthermore, chrysin also inhibits multi‑drug resistant proteins and is effective in combination therapy. The present review comprehensively discusses the research developments in the understanding of the potential of chrysin as a potent anticancer agent achieved by modulating various cell targets and signaling pathways involved in inflammation, cell survival, apoptosis, growth, angiogenesis, invasion and metastasis.
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September-October 2024
Volume 6 Issue 5

Print ISSN: 2632-2900
Online ISSN:2632-2919

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Spandidos Publications style
Raina R, Bhatt R and Hussain A: Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Acad Sci J 6: 45, 2024
APA
Raina, R., Bhatt, R., & Hussain, A. (2024). Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Academy of Sciences Journal, 6, 45. https://doi.org/10.3892/wasj.2024.260
MLA
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6.5 (2024): 45.
Chicago
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6, no. 5 (2024): 45. https://doi.org/10.3892/wasj.2024.260