Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

Shang,Xifu; Luo,Zhengliang; Li,Xu; Hu,Fei; Zhao,Qichun; Zhang,Wenzhi

doi:10.3892/br.2013.93

Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

Authors:
- Xifu Shang
- Zhengliang Luo
- Xu Li
- Fei Hu
- Qichun Zhao
- Wenzhi Zhang
View Affiliations

Affiliations: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
Published online on: April 9, 2013 https://doi.org/10.3892/br.2013.93
Pages: 594-598

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Testing for genetic risk associations between Factor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta‑analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75‑7.52, P<0.00001). This meta‑analysis demonstrated that FVL plays an important role in non‑Asian populations. Large sample studies including different ethnic groups and age‑ and gender‑matched groups, as well as multiple gene polymorphism detection should be considered to clarify the association of FVL mutation polymorphism and ONFH susceptibility in the future.

View Figures

View References

1	Malizos KN, Karantanas AH, Varitimidis SE, Dailiana ZH, Bargiotas K and Maris T: Osteonecrosis of the femoral head: etiology, imaging and treatment. Eur J Radiol. 63:16–28. 2007. View Article : Google Scholar : PubMed/NCBI
2	Jones LC and Hungerford DS: Osteonecrosis: etiology, diagnosis, and treatment. Curr Opin Rheumatol. 16:443–449. 2004. View Article : Google Scholar : PubMed/NCBI
3	Lafforgue P: Pathophysiology and natural history of avascular necrosis of bone. Joint Bone Spine. 73:500–507. 2006. View Article : Google Scholar : PubMed/NCBI
4	Rosing J and Tans G: Coagulation factor V: an old star shines again. Thromb Haemost. 78:427–433. 1997.PubMed/NCBI
5	Bertina RM, Koeleman BPC, Koster T, et al: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 369:64–67. 1994. View Article : Google Scholar : PubMed/NCBI
6	Dentali F, Ageno W, Bozzato S, et al: Role of factor V Leiden or G20210A prothrombin mutation in patients with symptomatic pulmonary embolism and deep vein thrombosis: a meta-analysis of the literature. J Thromb Haemost. 10:732–737. 2012. View Article : Google Scholar : PubMed/NCBI
7	Dowaidar M and Settin A: Risk of myocardial infarction related to factor V Leiden mutation: a meta-analysis. Genet Test Mol Biomarkers. 14:493–498. 2010. View Article : Google Scholar : PubMed/NCBI
8	Bjorkman A, Svensson PJ, Hillarp A, Burtscher IM, Runow A and Benoni G: Factor V leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults. Clin Orthop Relat Res. 452:168–172. 2004. View Article : Google Scholar : PubMed/NCBI
9	Celik A, Tekis D, Saglam F, et al: Association of corticosteroids and factor V, prothrombin, and MTHFR gene mutations with avascular osteonecrosis in renal allograft recipients. Transplant Proc. 38:512–516. 2006. View Article : Google Scholar : PubMed/NCBI
10	Ekmekci Y, Keven K, Akar N, et al: Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients. Nephrol Dial Transplant. 21:3555–3558. 2006. View Article : Google Scholar : PubMed/NCBI
11	Glueck CJ, Fontaine RN, Gruppo R, et al: The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin Orthop Relat Res. 366:133–146. 1999. View Article : Google Scholar : PubMed/NCBI
12	Glueck CJ, Freiberg RA, Boppana S and Wang P: Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis. J Bone Joint Surg Am. 90:2220–2229. 2008. View Article : Google Scholar : PubMed/NCBI
13	Glueck CJ, Freiberg RA, Boriel G, et al: The role of the factor V Leiden mutation in osteonecrosis of the hip. Clin Appl Thromb Hemost. June 12–2012.(Epub ahead of print).
14	Zalavras CG, Vartholomatos G, Dokou E and Malizos KN: Genetic background of osteonecrosis: associated with thrombophilic mutations? Clin Orthop Relat Res. 251–255. 2004.PubMed/NCBI
15	Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI
16	Cochran WG: The combination of estimates from different experiments. Biometrics. 10:101–129. 1954. View Article : Google Scholar
17	Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI
18	Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI
19	Jones JP Jr: Intravascular coagulation and osteonecrosis. Clin Orthop Relat Res. 277:41–53. 1992.PubMed/NCBI
20	Jones JP Jr: Coagulopathies and osteonecrosis. Acta Orthop Belg. 65(Suppl 1): 5–8. 1999.
21	Lowe GD, Rumley A, Woodward M, Reid E and Rumley J: Activated protein C resistance and the FV: R506Q mutation in a random population sample-associations with cardiovascular risk factors and coagulation variables. Thromb Haemost. 81:918–924. 1999.PubMed/NCBI
22	Chang JD, Hur M, Lee SS, Yoo JH and Lee KM: Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. Clin Orthop Relat Res. 466:1041–1046. 2008. View Article : Google Scholar : PubMed/NCBI
23	Kechli AM, Wilimas JA, Pui CH, Park VM, Tonkel S and Deitcher SR: Factor V Leiden and other hypercoagulable state mutations are not associated with osteonecrosis during or after treatment for pediatric malignancy. J Pediatr. 134:310–314. 1999. View Article : Google Scholar
24	Sun W, Li ZR, Shi ZC, et al: Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis. Zhonghua Yi Xue Za Zhi. 86:442–445. 2006.(In Chinese).
25	Jun ZJ, Ping T, Lei Y, Li L, Ming SY and Jing W: Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism. Clin Lab Haematol. 28:111–116. 2006. View Article : Google Scholar : PubMed/NCBI
26	Kim YW, Yoon KY, Park S, Shim YS, Cho HI and Park SS: Absence of factor V Leiden mutation in Koreans. Thromb Res. 86:181–182. 1997.PubMed/NCBI
27	De Stefano V, Chiusolo P, Paciaroni K and Leone G: Epidemiology of factor V Leiden: clinical implications. Semin Thromb Hemost. 24:367–379. 1998.PubMed/NCBI
28	Rosendorff A and Dorfman DM: Activated protein C resistance and factor V Leiden: a review. Arch Pathol Lab Med. 131:866–871. 2007.PubMed/NCBI
29	Frosst P, Blom HJ, Milos R, et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 10:111–113. 1995. View Article : Google Scholar : PubMed/NCBI
30	Eldibany MM and Caprini JA: Hyperhomocysteinemia and thrombosis: an overview. Arch Pathol Lab Med. 131:872–884. 2007.PubMed/NCBI
31	Rosendaal FR, Doggen CJ, Zivelin A, et al: Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost. 79:706–708. 1998.PubMed/NCBI