Open Access

Animal models of atherosclerosis (Review)

  • Authors:
    • Yee Ting Lee
    • Victoria Laxton
    • Hiu Yu Lin
    • Yin Wah Fiona Chan
    • Sophia  Fitzgerald‑Smith
    • Tsz Ling Olivia To
    • Bryan P Yan
    • Tong Liu
    • Gary Tse
  • View Affiliations

  • Published online on: Tuesday, January 17, 2017
  • Pages:259-266 DOI: 10.3892/br.2017.843
  • Copyright : © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

0

Abstract

Atherosclerosis is a significant cause of morbidity and mortality globally. Many animal models have been developed to study atherosclerosis, and permit experimental conditions, diet and environmental risk factors to be carefully controlled. Pathophysiological changes can be produced using genetic or pharmacological means to study the harmful consequences of different interventions. Experiments using such models have elucidated its molecular and pathophysiological mechanisms, and provided platforms for pharmacological development. Different models have their own advantages and disadvantages, and can be used to answer different research questions. In the present review article, different species of atherosclerosis models are outlined, with discussions on the practicality of their use for experimentation.

Related Articles

Journal Cover

March 2017
Volume 6 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lee, Y.T., Laxton, V., Lin, H.Y., Chan, Y.W., Fitzgerald‑Smith, S., To, T. ... Tse, G. (2017). Animal models of atherosclerosis (Review). Biomedical Reports, 6, 259-266. http://dx.doi.org/10.3892/br.2017.843
MLA
Lee, Y. T., Laxton, V., Lin, H. Y., Chan, Y. W., Fitzgerald‑Smith, S., To, T., Yan, B. P., Liu, T., Tse, G."Animal models of atherosclerosis (Review)". Biomedical Reports 6.3 (2017): 259-266.
Chicago
Lee, Y. T., Laxton, V., Lin, H. Y., Chan, Y. W., Fitzgerald‑Smith, S., To, T., Yan, B. P., Liu, T., Tse, G."Animal models of atherosclerosis (Review)". Biomedical Reports 6, no. 3 (2017): 259-266. http://dx.doi.org/10.3892/br.2017.843