Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis

  • Authors:
    • Junya De Lacorte Singulani
    • Julhiany De Fátima Da Silva
    • Fernanda Patricia Gullo
    • Marina Célia Costa
    • Ana Marisa Fusco‑Almeida
    • Francisco Javier Enguita
    • Maria José Soares Mendes‑Giannini
  • View Affiliations

  • Published online on: January 26, 2017     https://doi.org/10.3892/br.2017.849
  • Pages: 353-357
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are small RNAs (length, 19-24 nucleotides) that regulate gene expression by either mRNA degradation or translational inhibition of proteins. Circulating miRNAs, which are extremely stable and protected from RNAse‑mediated degradation in body fluids, have appeared as candidate biomarkers for numerous diseases. However, little is known about circulating miRNAs in fungal infections. Paracoccidioidomycosis (PCM) is caused by the Paracoccidioides species, and is endemic in Central and South America, with predominance in adult male workers from rural areas. The current study aimed to identify a serum miRNA expression profile that could serve as a novel diagnostic biomarker for PCM. Total RNA was isolated and the levels of circulating miRNAs were compared between patients with PCM and healthy control subjects using reverse transcription‑quantitative polymerase chain reaction. Bioinformatic analysis was used to evaluate the potential roles of these miRNAs in PCM. Eight miRNAs were differentially expressed in serum samples from patients with PCM. These miRNAs are associated with apoptosis and immune response. The identified miRNAs facilitate with understanding the regulatory mechanisms involved in the host‑parasite interaction of PCM. Furthermore, considering that the diagnosis of PCM presents difficulties, these miRNAs may serve as novel biomarkers for this disease.
View Figures
View References

Related Articles

Journal Cover

March-2017
Volume 6 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Singulani JD, Da Silva JD, Gullo FP, Costa MC, Fusco‑Almeida A, Enguita FJ and Mendes‑Giannini MS: Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis. Biomed Rep 6: 353-357, 2017
APA
Singulani, J.D., Da Silva, J.D., Gullo, F.P., Costa, M.C., Fusco‑Almeida, A., Enguita, F.J., & Mendes‑Giannini, M.S. (2017). Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis. Biomedical Reports, 6, 353-357. https://doi.org/10.3892/br.2017.849
MLA
Singulani, J. D., Da Silva, J. D., Gullo, F. P., Costa, M. C., Fusco‑Almeida, A., Enguita, F. J., Mendes‑Giannini, M. S."Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis". Biomedical Reports 6.3 (2017): 353-357.
Chicago
Singulani, J. D., Da Silva, J. D., Gullo, F. P., Costa, M. C., Fusco‑Almeida, A., Enguita, F. J., Mendes‑Giannini, M. S."Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis". Biomedical Reports 6, no. 3 (2017): 353-357. https://doi.org/10.3892/br.2017.849