Role of the microRNA-29 family in fibrotic skin diseases (Review)
- Authors:
- Duygu Harmanci
- Erdogan Pekcan Erkan
- Ayse Kocak
- Gul Guner Akdogan
-
Affiliations: Department of Molecular Medicine, Graduate School of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey, Department of Medical Genetics, Medicum, University of Helsinki, 00014 Helsinki, Finland, Department of Medical Biochemistry, School of Medicine, Izmir University of Economics, Balcova 35330, Izmir, Turkey - Published online on: May 3, 2017 https://doi.org/10.3892/br.2017.900
- Pages: 599-604
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|
Gardet A, Zheng TS and Viney JL: Genetic architecture of human fibrotic diseases: Disease risk and disease progression. Front Pharmacol. 4:1592013. View Article : Google Scholar : PubMed/NCBI | |
|
Vassiliadis E, Veidal SS, Barascuk N, Mullick JB, Clausen RE, Larsen L, Simonsen H, Larsen DV, Bay-Jensen AC, Segovia-Silvestre T, et al: Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis. BMC Dermatol. 11:62011. View Article : Google Scholar : PubMed/NCBI | |
|
Babalola O, Mamalis A, Lev-Tov H and Jagdeo J: The role of microRNAs in skin fibrosis. Arch Dermatol Res. 305:763–776. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Jinnin M: Various applications of microRNAs in skin diseases. J Dermatol Sci. 74:3–8. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JM, Hansen NU, Bay-Jensen AC, Bager CL, Krag A, et al: Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 308:G807–G830. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang X, Tsitsiou E, Herrick SE and Lindsay MA: MicroRNAs and the regulation of fibrosis. FEBS J. 277:2015–2021. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jinnin M: Mechanisms of skin fibrosis in systemic sclerosis. J Dermatol. 37:11–25. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Vettori S, Gay S and Distler O: Role of microRNAs in fibrosis. Open Rheumatol J. 6:130–139. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Villarreal G Jr, Oh DJ, Kang MH and Rhee DJ: Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork. Invest Ophthalmol Vis Sci. 52:3391–3397. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wynn TA: Cellular and molecular mechanisms of fibrosis. J Pathol. 214:199–210. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Almeida MI, Reis RM and Calin GA: MicroRNA history: Discovery, recent applications, and next frontiers. Mutat Res. 717:1–8. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bhaskaran M and Mohan M: MicroRNAs: History, biogenesis, and their evolving role in animal development and disease. Vet Pathol. 51:759–774. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Bushati N and Cohen SM: MicroRNA functions. Annu Rev Cell Dev Biol. 23:175–205. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Erkan EP, Breakefield XO and Saydam O: miRNA signature of schwannomas: Possible role(s) of ‘tumor suppressor’ miRNAs in benign tumors. Oncotarget. 2:265–270. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Senol O, Schaaij-Visser TB, Erkan EP, Dorfer C, Lewandrowski G, Pham TV, Piersma SR, Peerdeman SM, Ströbel T, Tannous B, et al: miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo. Oncogene. 34:1790–1798. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Huang J, Guo M and Zuo X: MicroRNAs Regulating Signaling Pathways: Potential Biomarkers in Systemic Sclerosis. Genomics Proteomics Bioinformatics. 13:234–241. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Noetel A, Kwiecinski M, Elfimova N, Huang J and Odenthal M: microRNA are Central Players in Anti- and Profibrotic Gene Regulation during Liver Fibrosis. Front Physiol. 3:492012. View Article : Google Scholar : PubMed/NCBI | |
|
Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV and Lü J: miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 45:287–294. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Kapinas K, Kessler C, Ricks T, Gronowicz G and Delany AM: miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem. 285:25221–25231. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kapinas K, Kessler CB and Delany AM: miR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling. J Cell Biochem. 108:216–224. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kriegel AJ, Liu Y, Fang Y, Ding X and Liang M: The miR-29 family: Genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics. 44:237–244. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Maurer B, Stanczyk J, Jüngel A, Akhmetshina A, Trenkmann M, Brock M, Kowal-Bielecka O, Gay RE, Michel BA, Distler JH, et al: MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 62:1733–1743. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Zhang X, Li H, Yu J and Ren X: The role of miRNA-29 family in cancer. Eur J Cell Biol. 92:123–128. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Ghazwani M, Li J, Sun M, Stolz DB, He F, Fan J, Xie W and Li S: miR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase. Biochem Biophys Res Commun. 446:940–944. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ruvkun G: Molecular biology. Glimpses of a tiny RNA world. Science. 294:797–799. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403:901–906. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Carthew RW and Sontheimer EJ: Origins and mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ameres SL and Zamore PD: Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 14:475–488. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW and Fernandez-Zapico ME: Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem. 110:1155–1164. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kole AJ, Swahari V, Hammond SM and Deshmukh M: miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev. 25:125–130. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mott JL, Kobayashi S, Bronk SF and Gores GJ: mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 26:6133–6140. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wei W, He HB, Zhang WY, Zhang HX, Bai JB, Liu HZ, Cao JH, Chang KC, Li XY and Zhao SH: miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. Cell Death Dis. 4:e6682013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu K, Liu L, Zhang J, Wang Y, Liang H, Fan G, Jiang Z, Zhang CY, Chen X and Zhou G: MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6. Protein Cell. 7:434–444. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Roderburg C and Luedde T: Circulating microRNAs as markers of liver inflammation, fibrosis and cancer. J Hepatol. 61:1434–1437. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Roderburg C, Urban GW, Bettermann K, Vucur M, Zimmermann H, Schmidt S, Janssen J, Koppe C, Knolle P, Castoldi M, et al: Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology. 53:209–218. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cushing L, Kuang P and Lü J: The role of miR-29 in pulmonary fibrosis. Biochem Cell Biol. 93:109–118. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yang T, Liang Y, Lin Q, Liu J, Luo F, Li X, Zhou H, Zhuang S and Zhang H: miR-29 mediates TGFβ1-induced extracellular matrix synthesis through activation of PI3K-AKT pathway in human lung fibroblasts. J Cell Biochem. 114:1336–1342. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Maegdefessel L, Azuma J and Tsao PS: MicroRNA-29b regulation of abdominal aortic aneurysm development. Trends Cardiovasc Med. 24:1–6. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA and Olson EN: Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA. 105:pp. 13027–13032. 2008; View Article : Google Scholar : PubMed/NCBI | |
|
Wang G, Kwan BC, Lai FM, Chow KM, Li PK and Szeto CC: Urinary miR-21, miR-29, and miR-93: Novel biomarkers of fibrosis. Am J Nephrol. 36:412–418. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kawashita Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Masuguchi S, Fukushima S, Inoue Y and Ihn H: Circulating miR-29a levels in patients with scleroderma spectrum disorder. J Dermatol Sci. 61:67–69. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
O'Reilly S: miRNA-29a in systemic sclerosis: A valid target. Autoimmunity. 48:511–512. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Peng WJ, Tao JH, Mei B, Chen B, Li BZ, Yang GJ, Zhang Q, Yao H, Wang BX, He Q, et al: MicroRNA-29: A potential therapeutic target for systemic sclerosis. Expert Opin Ther Targets. 16:875–879. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kapinas K and Delany AM: MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther. 13:2202011. View Article : Google Scholar : PubMed/NCBI | |
|
Knabel MK, Ramachandran K, Karhadkar S, Hwang HW, Creamer TJ, Chivukula RR, Sheikh F, Clark KR, Torbenson M, Montgomery RA, et al: Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice. PLoS One. 10:e01244112015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Chu ES, Chen HY, Man K, Go MY, Huang XR, Lan HY, Sung JJ and Yu J: microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway. Oncotarget. 6:7325–7338. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao J, Meng XM, Huang XR, Chung AC, Feng YL, Hui DS, Yu CM, Sung JJ and Lan HY: miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol Ther. 20:1251–1260. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M and Ding X: miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. Am J Physiol Renal Physiol. 304:F1274–F1282. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ and Lan HY: TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol. 22:1462–1474. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ciechomska M, O'Reilly S, Suwara M, Bogunia-Kubik K and van Laar JM: miR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis. PLoS One. 9:e1155962014. View Article : Google Scholar : PubMed/NCBI | |
|
Jafarinejad-Farsangi S, Farazmand A, Mahmoudi M, Gharibdoost F, Karimizadeh E, Noorbakhsh F, Faridani H and Jamshidi AR: MicroRNA-29a induces apoptosis via increasing the Bax: Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. Autoimmunity. 48:369–378. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Steele R, Mott JL and Ray RB: MBP-1 upregulates miR-29b that represses Mcl-1, collagens, and matrix-metalloproteinase-2 in prostate cancer cells. Genes Cancer. 1:381–387. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Takemoto R, Jinnin M, Wang Z, Kudo H, Inoue K, Nakayama W, Ichihara A, Igata T, Kajihara I, Fukushima S, et al: Hair miR-29a levels are decreased in patients with scleroderma. Exp Dermatol. 22:832–833. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu H, Luo H and Zuo X: MicroRNAs: Their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma. Exp Mol Med. 45:e412013. View Article : Google Scholar : PubMed/NCBI | |
|
Pavletic SZ and Fowler DH: Are we making progress in GVHD prophylaxis and treatment? Hematology Am Soc Hematol Educ Program. 2012:251–264. 2012.PubMed/NCBI | |
|
Paczesny S, Raiker N, Brooks S and Mumaw C: Graft-versus-host disease biomarkers: Omics and personalized medicine. Int J Hematol. 98:275–292. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao B, Wang Y, Li W, Baker M, Guo J, Corbet K, Tsalik EL, Li QJ, Palmer SM, Woods CW, et al: Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. Blood. 122:3365–3375. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Atarod S and Dickinson AM: MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease? Front Immunol. 4:4202013. View Article : Google Scholar : PubMed/NCBI | |
|
Hahn JM, McFarland KL, Combs KA and Supp DM: Partial epithelial-mesenchymal transition in keloid scars: Regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns Trauma. 4:302016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang GY, Wu LC, Liao T, Chen GC, Chen YH, Zhao YX, Chen SY, Wang AY, Lin K, Lin DM, et al: A novel regulatory function for miR-29a in keloid fibrogenesis. Clin Exp Dermatol. 41:341–345. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Yang D, Xiao Z and Zhang M: miRNA expression profiles in keloid tissue and corresponding normal skin tissue. Aesthetic Plast Surg. 36:193–201. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lian N and Li T: Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications. Biomed Pharmacother. 84:42–50. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ning P, Liu DW, Mao YG, Peng Y, Lin ZW and Liu DM: Differential expression profile of microRNA between hyperplastic scar and normal skin]. Zhonghua Yi Xue Za Zhi. 92:692–694. 2012.(In Chinese). PubMed/NCBI | |
|
Guo J, Lin Q, Shao Y, Rong L and Zhang D: miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway. Can J Physiol Pharmacol. 95:437–442. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou R, Zhang Q, Zhang Y, Fu S and Wang C: Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Exp Cell Res. 339:360–366. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li G, Zhou R, Zhang Q, Jiang B, Wu Q and Wang C: Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts. Exp Cell Res. 345:93–99. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Mu S, Kang B, Zeng W, Sun Y and Yang F: MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway. Mol Cell Biochem. 416:99–108. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Gay S, Distler O and Maurer B: Treatment of scleroderma US Patent US20110218233 A1. Filed September 4, 2009; issued September 8. 2011 | |
|
Zhu JN, Chen R, Fu YH, Lin QX, Huang S, Guo LL, Zhang MZ, Deng CY, Zou X, Zhong SL, et al: Smad3 inactivation and miR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. PLoS One. 8:e755572013. View Article : Google Scholar : PubMed/NCBI |
