Open Access

Pituitary adenylate cyclase-activating polypeptide attenuates tumor necrosis factor-α-induced apoptosis in endothelial colony-forming cells

  • Authors:
    • Ning Bian
    • Gang Du
    • Man Fai Ip
    • Juan Ding
    • Qing Chang
    • Zicheng Li
  • View Affiliations

  • Published online on: May 23, 2017     https://doi.org/10.3892/br.2017.917
  • Pages:11-16
0

Abstract

Endothelial colony-forming cells (ECFCs) are important in angiogenesis and vascular proliferation. Tumor necrosis factor (TNF)-α is a significant risk factor for the development of atherosclerosis and a key proinflammatory cytokine known to induce apoptosis in endothelial cells. Pituitary adenylate cyclase‑activating polypeptide (PACAP) is one of the members of the vasoactive intestinal peptide/secretin/growth hormone‑releasing hormone/glucagon superfamily and exists in two biological active forms, PACAP 38 and PACAP 27. PACAP has been reported to help prevent endothelial apoptosis via an anti-inflammatory mechanism. However, to the best of our knowledge, the anti‑apoptotic potential of PACAP has not been investigated in ECFCs. The aim of the present study was to demonstrate the efficacy of PACAP for decreasing TNF‑α‑induced apoptosis in ECFCs. The results indicated that PACAP exerts a cytoprotective effect on ECFCs exposed to TNF‑α. Furthermore, PACAP partially rescues the proliferation potential of ECFCs inhibited by prolonged TNF‑α exposure. These findings support an anti‑inflammatory role for PACAP in circulation diseases.

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July 2017
Volume 7 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Bian, N., Du, G., Ip, M.F., Ding, J., Chang, Q., & Li, Z. (2017). Pituitary adenylate cyclase-activating polypeptide attenuates tumor necrosis factor-α-induced apoptosis in endothelial colony-forming cells. Biomedical Reports, 7, 11-16. https://doi.org/10.3892/br.2017.917
MLA
Bian, N., Du, G., Ip, M. F., Ding, J., Chang, Q., Li, Z."Pituitary adenylate cyclase-activating polypeptide attenuates tumor necrosis factor-α-induced apoptosis in endothelial colony-forming cells". Biomedical Reports 7.1 (2017): 11-16.
Chicago
Bian, N., Du, G., Ip, M. F., Ding, J., Chang, Q., Li, Z."Pituitary adenylate cyclase-activating polypeptide attenuates tumor necrosis factor-α-induced apoptosis in endothelial colony-forming cells". Biomedical Reports 7, no. 1 (2017): 11-16. https://doi.org/10.3892/br.2017.917