Serum pepsinogen and gastrin‑17 as potential biomarkers for pre‑malignant lesions in the gastric corpus

  • Authors:
    • Tan Han Loong
    • Ngiu Chai Soon
    • Nik Ritza Kosai Nik Mahmud
    • Jeevinesh Naidu
    • Rafiz Abdul Rani
    • Nazefah Abdul Hamid
    • Marjanu Hikmah Elias
    • Isa Mohamed Rose
    • Azmi Tamil
    • Norfilza M. Mokhtar
    • Raja Affendi Raja Ali
  • View Affiliations

  • Published online on: September 20, 2017     https://doi.org/10.3892/br.2017.985
  • Pages: 460-468
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Abstract

There is a lack of non‑invasive screening modalities to diagnose chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). Thus, the aim of the present study was to determine the sensitivity and specificity of serum pepsinogen I (PGI), PGI:II, the PGI:II ratio and gastrin‑17 (G‑17) in diagnosing CAG and IM, and the correlations between these serum biomarkers and pre‑malignant gastric lesions. A cross‑sectional study of 72 patients (82% of the calculated sample size) who underwent oesophageal‑gastro‑duodenoscopy for dyspepsia was performed in the present study. The mean age of the participants was 56.2±16.2 years. Serum PGI:I, PGI:II, G‑17 and Helicobacter pylori antibody levels were measured by enzyme‑linked immunosorbent assay. Median levels of PGI:I, PGI:II, the PGI:II ratio and G‑17 for were 129.9 µg/l, 10.3 µg/l, 14.7 and 4.4 pmol/l, respectively. Subjects with corpus CAG/IM exhibited a significantly lower PGI:II ratio (7.2) compared with the control group (15.7; P<0.001). Histological CAG and IM correlated well with the serum PGI:II ratio (r=‑0.417; P<0.001). The cut‑off value of the PGI:II ratio of ≤10.0 demonstrated high sensitivity (83.3%), specificity (77.9%) and area under the receiver operating characteristic curve of 0.902 in detecting the two conditions. However, the sensitivity was particularly low at a ratio of ≤3.0. The serum PGI:II ratio is a sensitive and specific marker to diagnose corpus CAG/IM, but at a high cut‑off value. This ratio may potentially be used as an outpatient, non‑invasive biomarker for detecting corpus CAG/IM.
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November-2017
Volume 7 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Loong TH, Soon NC, Nik Mahmud NR, Naidu J, Rani RA, Abdul Hamid N, Elias MH, Mohamed Rose I, Tamil A, Mokhtar NM, Mokhtar NM, et al: Serum pepsinogen and gastrin‑17 as potential biomarkers for pre‑malignant lesions in the gastric corpus. Biomed Rep 7: 460-468, 2017
APA
Loong, T.H., Soon, N.C., Nik Mahmud, N.R., Naidu, J., Rani, R.A., Abdul Hamid, N. ... Raja Ali, R.A. (2017). Serum pepsinogen and gastrin‑17 as potential biomarkers for pre‑malignant lesions in the gastric corpus. Biomedical Reports, 7, 460-468. https://doi.org/10.3892/br.2017.985
MLA
Loong, T. H., Soon, N. C., Nik Mahmud, N. R., Naidu, J., Rani, R. A., Abdul Hamid, N., Elias, M. H., Mohamed Rose, I., Tamil, A., Mokhtar, N. M., Raja Ali, R. A."Serum pepsinogen and gastrin‑17 as potential biomarkers for pre‑malignant lesions in the gastric corpus". Biomedical Reports 7.5 (2017): 460-468.
Chicago
Loong, T. H., Soon, N. C., Nik Mahmud, N. R., Naidu, J., Rani, R. A., Abdul Hamid, N., Elias, M. H., Mohamed Rose, I., Tamil, A., Mokhtar, N. M., Raja Ali, R. A."Serum pepsinogen and gastrin‑17 as potential biomarkers for pre‑malignant lesions in the gastric corpus". Biomedical Reports 7, no. 5 (2017): 460-468. https://doi.org/10.3892/br.2017.985